Background
Brain cancers now account for more cancer deaths in the under 40s than any other cancer. Adult gliomas account for the majority of the ~5000 cases of malignant brain tumours in the UK each year.
There are over 150 brain tumour types. They can be classified based on the type of cell they grow from, their location in the brain and how likely they are to spread. Tumours are graded by the cell activity and aggressiveness on a scale of I to IV. Treatment options vary depending on the cell type, grade, size, and location of the tumour.
The most common type of primary brain cancer in adults is glioblastoma originating from glial cells. Glioblastoma spreads quickly and invades other parts of the brain. It is challenging to treat.
Brain cancer survival remains low and has changed little in over a generation. With over 11,000 new cases of brain tumours in the UK each year and 10-year survival rate of less than 15%, there is a pressing need for development of better treatments.
We aim to deliver a step change in glioma research in the UK. We will bring together world-leading experts to advance our understanding of the biology underpinning the disease and to explore new avenues for diagnosis and personalised treatment.
Research focus and strategic partnerships

About the Centre
Transforming the UK landscape for discovery and clinical evaluation of new brain cancer therapeutics for glioblastoma.

Glioma Cellular Genetics Resource
A collection of cellular models and associated data to underpin the next era of studies into the biology and treatment of glioma.
Patient engagement
Connecting researchers with patients and the public to improve patient outcomes.
Research engagement is a priority for UCL and the CRUK-UCL Centre. By sharing and discussing their work with patients, our scientists are able to show how research at UCL is fundamental to developing new processes and kinder therapies that can help more people survive their cancer.
Our dedicated CRUK Research Engagement Manager, works with researchers to showcase the cancer research being carried out at UCL through lab tours, open days and other events. Over the past year, UCL researchers have supported and delivered around 30 events, with over 40 different scientists from across UCL spreading news about our research to almost 2,000 people.
The UCL Public Engagement Unit exists to champion UCL's founding principle of open education and access to knowledge. At the core of public/patient engagement is the idea of two way dialogue connecting higher education research and teaching with the world outside. The Public Engagement Team help UCL staff and students listen to and engage with communities.

News and features

Aggressive brain tumours can mimic normal brain repair processes
The UCL Parrinello Lab has discovered that glioblastoma, an aggressive brain cancer, mimics normal brain repair in white matter, which leads to the tumour becoming less malignant.

Brain cancer trial recruits largest ever number of patients
The IPI-GLIO clinical trial for patients with glioblastoma brain cancer has recruited a record number of UK participants for a study of its kind.