Near Infrared Spectroscopy

The Near Infrared Spectroscopy group is part of the Biomedical Optics Research Laboratory in the Department of Medical Physics and Bioengineering at University College London. The group consists of postdoctoral researchers and PhD students with expertise in physics, engineering and mathematics. We are supported by a number of UKRI and charitable grants and industrial sponsorship.

The work of our group is focused on the development and application of a wide range of near infrared spectroscopy instrumentation including single and multi channel differential, spatially resolved and phase resolved systems. These systems are designed to measure tissue oxygenation, haemodynamics and metabolism in a number of different organs although our current focus is predominantly on the brain and muscle. We have long standing collaborations with a range of clinical and life science groups, as well as Hamamatsu Photonics and Hitachi Medical.

Current Projects

Instrumentation Development

Hybrid System
Blood Flow Monitor System
Portable Wireless System
Dynamic Phantom using Liquid Crystal Display

Mathematical Modelling

Functional Activation Studies

Trainee Surgeons
Numerical Studies on Twins
Software Development
- Functional Optical Signal Analysis (fOSA)

Clinical Studies

Muscle Applications

Olympic Atheletes
Spinal Cord Injured Patients

Publications

Publications by our researchers are available at our searchable UCL Research Publication Service

Posters

2012-2013

fNIRS Oct 12

Reduction of cytochrome c oxidase during vasovagal hypoxia-ischaemia in human adult brain: a case study

Ghosh A, Tachtsidis I, Kolyva C, Highton D, Elwell C, Smith M.

Functional Near Infrared Spectroscopy Meeting 2012, London, UK (October 2012)

ISOTT Aug 12

Dependence on NIRS source-detector spacing of cytochrome c oxidase response to hypoxia and hypercapnia in the adult brain.

Kolyva C, Ghosh A, Tachtsidis I, Highton D, Smith M, Elwell CE.

Conference of the International Society of Oxygen Transport to Tissue 2012, Bruges, Belgium (Aug 2012)

UCL June 12

Normobaric hyperoxia increases cerebral cytochrome c oxidase oxidation after acute brain injury.

Ghosh A, Tachtsidis I, Kolyva C, Highton D, Elwell C, Smith M.

UCL Neuroscience Symposium 2012, London, UK (June 2012)

OSA BIOMED May 12

Individualised optimisation of modelled cerebral oxygenation near-infrared spectroscopy signals.

Jelfs B, Panovska-Griffiths J, Tachtsidis I, Banaji M, Elwell C.

Optical Society of America Biomedical Optics Topical Meeting 2012, Miami, USA (May 2012)

ISICEM March 12

Deoxyhaemoglobin as a biomarker of cerebral autoregulation.

Highton DT, Ghosh A, Panovska J, Tachtsidis I, Kolyva C, Elwell CE, Smith M.

International Symposium on Intensive Care and Emergency Medicine 2012, Brussels, Belgium (March 2012)

2010-2011

SNACC Oct 11

Low frequency oscillations of NIRS in brain injury: relation to flow, intracranial pressure and blood pressure.

Highton DT, Ghosh A, Bal J, Tachtsidis I, Kolyva C, Elwell CE, Smith M.

Annual Meeting of the Society for Neuroscience in Anesthesiology and Critical Care 2011, Chicago, USA (October 2011)

BRAIN May 11

Near infrared spectroscopy as a measure of vascular reactivity in brain injury.

Highton DT, Ghosh A, Bal J, Tachtsidis I, Kolyva C, Elwell CE, Smith M.

International Symposium on Cerebral Blood Flow, Metabolism and Function 2011, Barcelona, Spain (May 2011)

SNACC Oct 10

A comparison between pressure reactivity index,mean velocity index and near infrared spectroscopy in brain injury.

Highton DT, Ghosh A, Tachisidis I, Kolyva C, Elwell CE, Smith M.

Annual Meeting of the Society for Neuroscience in Anesthesiology and Critical Care 2010, San Diego, USA (October 2010)

ISOTT July 10

Investigation of regional cerebral oxygenation and haemodynamics in infants and children supported on ECMO.

Papademetriou MD, Tachtsidis I, Banaji M, Elliott MJ, Hoskote A, Elwell CE.

Conference of the International Society of Oxygen Transport to Tissue 2010, Ascona, Switzerland (July 2010)

UCL March 10

Using Near Infrared Spectroscopy to monitor brain oxygenation in infants and children with cardiac defects.

Papademetriou MD, Tachtsidis I, Leung TS, Elliott MJ, Hoskote A, Elwell CE.

University College London Graduate School Research Poster Competition 2010, Runner-up prize in Built Environment, Engineering Sciences, Mathematical and Physical Sciences

2008-2009

ISOTT July 09

Quantification of systemic interference in optical topography data during frontal lobe and motor cortex activation: an independent component analysis.

Patel S, Katura T, Maki A, Tachtsidis I.

Conference of the International Society of Oxygen Transport to Tissue 2009, Cleveland, USA (July 2009)

BRAIN June 09

Hypercapnea does not consistently increase the oxidation of cytochrome c oxidase in traumatic brain injury.

Tachtsidis I, Pritchard C, Tisdall M, Leung T, Elwell C, Smith M.

International Symposium on Cerebral Blood Flow, Metabolism and Function, 2009, Chicago, USA, (June 2009)

ISOTT Aug 08

Functional optical topography analysis using statistical parametric mapping (SPM) methodology with and without physiological confounds.

Tachtsidis I, Koh PH, Stubbs C, Elwell CE.

Conference of the International Society of Oxygen Transport to Tissue 2008, Sapporo, Japan (Aug 2008)

ISOTT Aug 08

Modelling of mitochondrial oxygen consumption and NIRS detection of cytochrome oxidase.

Cooper CE, Mallet A, Elwell CE, Nicholls P, Tachtsidis I, Banaji M.

Conference of the International Society of Oxygen Transport to Tissue 2008, Sapporo, Japan (Aug 2008)

OSA BIOMED March 08

A hybrid multi-distance phase and broadband spatially resolved algorithm for resolving absolute concentrations of chromophores in the near-infrared light spectrum: results from studies in dynamic phantoms.

Tachtsidis I, Kohl-Bareis M, Leung TS, Gramer M, Tahir B, Cooper CE, Elwell CE.

Optical Society of America Biomedical Optics Topical Meeting 2008, St. Petersburg, USA (March 2008)

2006-2007

IRC Review April 07

Modelling the Cerebral Circulation.

Banaji M, Tachtsidis I, Donnell P, Delpy D, Baigent S.

IRC Review Meeting 2007, London, UK, (April 2007)

IRC Review April 07

The Application of the BRAINCIRC Model in Clinical Scenarios.

Tachtsidis I, Banaji M, Tisdall M, Smith M, Baigent S, Leung TS, Elwell CE, Delpy DT.

IRC Review Meeting 2007, London, UK, (April 2007)

Gordon Aug 06

The Application of a Model of Human Brain Circulation to Head Trauma Patients: A Computational Systems Biology Approach.

Tachtsidis I, Banaji M, Tisdall M, Smith M, Baigent S, Elwell CE, Delpy DT.

Gordon Conference 2006, Oxford, UK (Aug 2006)

NASGBI May 06

Changes in cerebral tissue oxygen saturation measured by near infrared spectroscopy do not only reflect changes in oxygenation.

Tisdall M, Tachtsidis I, Leung TS, Elwell CE, Smith M.

Annual Conference of the Neuroanaesthesia Society of Great Britain and Ireland 2006, Brighton, UK (May 2006)

OSA BIOMED March 06

Cerebral blood flow assessment with indocyanine green bolus transit detection by near-infrared spectroscopy before and after acetazolamide challenge in humans.

Tachtsidis I, Tisdall M, Leung TS, Delpy DT, Smith M, Elwell CE.

Optical Society of America Biomedical Optics Topical Meeting 2006, Fort Lauderdale, USA (March 2006)

OSA BIOMED March 06

Changes in concentrations of oxidised cytochrome oxidase measured using both broadband and four wavelength near infrared spectroscopy reflect changes in oxygen delivery during hypoxaemia in healthy volunteers.

Tisdall M, Tachtsidis I, Elwell CE, Smith M.

Optical Society of America Biomedical Optics Topical Meeting 2006, Fort Lauderdale, USA (March 2006)

ION Feb 06

Near infrared spectroscopic quantification of changes in the concentration of oxidised cytochrome oxidase in the healthy human brain during hypoxemia.

Tisdall M, Tachtsidis I, Elwell CE, Smith M.

Institute of Neurology Meeting 2006, London, UK (Feb 2006)

2004-2005

IRC Nov 05
Multimodal modelling simulation of hypercapnoeic challenge in acutely brain injured adult patient.
Tisdall M, Tachtsidis I, Banaji M, Delpy DT, Elwell CE, Smith M.
IRC Meeting 2005, Manchester, UK (Nov 2005).

ISOTT Aug 05 Investigation of frontal cortex, motor cortex and systemic haemodynamic changes during anagram solving.
Tachtsidis I, Leung TS, Tisdall M, Davendra P, Smith M, Delpy DT, Elwell CE.
Conference of the International Society of Oxygen Transport to Tissue 2005, Brisbane, Australia (Aug 2005)

BRAIN June 05 Investigation of the changes in cerebral tissue oxygenation measured with near infrared spectroscopy in response to moderate hypercapnia.
Tachtsidis I, Jones H, Oliver C, Delpy DT, Smith M, Elwell CE.
International Symposium on Cerebral Blood Flow, Metabolism and Function 2005, Amsterdam, The Netherlands (June 2005)

BRAIN June 05
Investigation of the cerebral haemoglobin and cytochrome signals using four wavelength non-invasive near infrared spectroscopy on patients with orthostatic hypotension.
Tisdall M, Tachtsidis I, Bleasdale-Barr K, Mathias CJ, Delpy DT, Elwell CE, Smith M.
International Symposium on Cerebral Blood Flow, Metabolism and Function 2005, Amsterdam, The Netherlands (June 2005)

OSA BIOMED April 04
Changes in cerebral total haemoglobin volume and cytochrome oxidase redox state during deep apnoeas in patients with obstructive sleep apnoea.
Tachtsidis I, Cooper CE, McGown AD, Makker H, Delpy DT, Elwell CE.
Optical Society of America Biomedical Optics Topical Meeting 2004, Miami, USA (April 2004)

2002-2003

ISOTT Aug 02
Spectral characteristics of spontaneous oscillations in cerebral haemodynamics are posture dependent.

Tachtsidis I, Elwell CE, Lee CW, Leung TS, Smith M, Delpy DT.

Conference of the International Society of Oxygen Transport to Tissue 2002, Manchester, UK (Aug 2002)