Tobias Goodwin-Allcock & Mar Estarellas Garcia - CMIC/WEISS Joint Seminar Series

Speaker: Tobias Goodwin-Allcock

Title:  TBC

Abstract: 
TBC

Speaker: Mar Estarellas Garcia

Title:  Alzheimer-like biomarker heterogeneity in a preclinical elderly birth cohort: Insight46

Abstract: 

Two main complexities of Alzheimer’s Disease (AD) arise from pathological changes (such as amyloid accumulation) occurring a decade or more before symptom onset, and AD being a highly heterogeneous disease with various clinical subtypes. Subtype and Stage Inference (SuStaIn), a data-driven modelling technique, has been previously applied to ADNI to better understand AD. Here we apply SuStaIn to Insight46, a sub-study of the British 1946 Birth Cohort to detect different trajectories of preclinical neurodegeneration.

Chair: Neil Oxtoby