UCL Centre for Medical Image Computing


Brian W. Pogue - CMIC/WEISS joint seminar series

20 January 2021, 1:00 pm–2:00 pm

Brian W. Pogue a talk as part of the CMIC/WEISS joint seminar series

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Title: Translational Biomedical Optics: Research, Development & Publishing

Abstract: The process of imaging medical treatments today is dominated by optical devices which are used at the point of care, in settings such as surgery and endoscopy.  These procedure-based tools are used together with radiologic devices to capture unique contrast features that help guide medical decisions about tissue removal and tissue response to therapy. In the developments in technologies and nanotechnologies within the world of Optics in Medicine have made major advances, such as image-guided spectroscopy during surgery, as well as surgical guidance navigation tools, and now radiologic guidance tools.  Examples from each will be used to highlight innovations in translational research that have gone from concept through to clinical trials, and now through to multicenter trial use.  In particular, nanotechnologies that bring together the strengths of radiation therapy and photodynamic therapy have the potential to advance cancer treatment by dose enhancement and better targeting.

Product development and publishing of discoveries has been a focus of this work, with a goal of translation beyond the initial feasibility phase.  Shifting emphasis away from academic publication towards impactful discovery necessarily involves more R&D which only companies can accomplish.  So, partnerships with companies in translational research has been paramount, and examples in surgical guidance can show this.  Translation through startup companies will be highlighted with a couple of examples, and a discussion of the limits to academic publishing as a measure of success.


Brian W. Pogue is the endowed MacLean Professor of Engineering at Dartmouth College and is an Adjunct Professor of Surgery in the Geisel School of Medicine, at Dartmouth.  He is co-director of the Translational Engineering in Cancer Program at the Norris Cotton Cancer Center at the Dartmouth-Hitchcock Medical Center.  His work is exploring the role that applied optical devices has in medicine, within the fields of biomedical engineering, medical physics, radiation therapy dosimetry, molecular guided surgery, photodynamic therapy and optically activated therapies. He has published over 400 peer-reviewed publications and is the Editor-in-Chief of the Journal of Biomedical Optics.  He recently founded companies DoseOptics LLC, making the world’s first camera FDA approved to image radiotherapy, and Quel Imaging LLC making standards for surgical guidance.


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