James Cole - CMIC-WEISS joint seminar series

James Cole

Centre for Medical Image Computing; Dementia Research Centre, University College London.

Title: Brain age: Neuroimaging of brain ageing in health and disease

Abstract: The brain changes as we age, and these changes are associated with cognitive decline and dementia risk. Neuroimaging can measure these age-related changes, and considerable variability in brain ageing patterns is evident. Equally, rates of age-associated decline affect people very differently. This motivates my research into ways of measuring the brain ageing process. Here I will present my work on ‘brain-age’, derived using machine learning, or deep learning, analysis of structural neuroimaging data. I will present results from brain-age studies of the general population and various diseases including Down’s syndrome, HIV, traumatic brain injury, epilepsy, multiple sclerosis and Alzheimer’s. I will also discuss my recent work on predicting brain-age using multiple MRI modalities in the UK Biobank. Finally, I will talk about ongoing developments, including voxelwise brain-age, and the efforts of the ENIGMA Brain Age working group.