MBPhD Programme


WRIGHT, Matthew James



Current Position:

Qualified 2000

PhD title:

In Vivo Myocardial Gene Transfer: Optimization and Evaluation of Gene Transfer Models & Vectors

Principal Supervisor:

Funding Source:

Description of Project:


Wright,M.J ., Rosenthal,E., Stewart,L., Wightman,L.M., Miller,A.D., Latchman,D.S., & Marber,M.S. (1998) beta-Galactosidase staining following intracoronary infusion of cationic liposomes in the in vivo rabbit heart is produced by microinfarction rather than effective gene transfer: a cautionary tale. Gene Ther., 5, 301-308.

Saurin,A.T., Martin,J.L., Heads,R.J., Foley,C., Mockridge,J.W., Wright,M.J., Wang,Y., & Marber,M.S. (2000) The role of differential activation of p38-mitogen-activated protein kinase in preconditioned ventricular myocytes. FASEB J., 14, 2237-2246.

Wright,M.J. , Wightman,L.M., Latchman,D.S., & Marber,M.S. (2001) In vivo myocardial gene transfer: optimization and evaluation of intracoronary gene delivery in vivo. Gene Ther., 8, 1833-1839.

Wright,M.J. , Wightman,L.M., Lilley,C., de Alwis,M., Hart,S.L., Miller,A., Coffin,R.S., Thrasher,A., Latchman,D.S., & Marber,M.S. (2001) In vivo myocardial gene transfer: optimization, evaluation and direct comparison of gene transfer vectors. Basic Res.Cardiol., 96, 227-236.

Edwards,R., Yousef,Z., Rakhit,R., Wright,M., Rosenthal,E., Redwood,S., & Marber,M. (2002) A model of closed chest regional myocardial infarction in the rabbit: a clinically relevant in vivo assay system of post-infarction remodelling. Basic Res.Cardiol., 97, 374-383