"Elucidating pathways of hair cell survival and protection"
Dr Sally Dawson, Jonathon Gale
Description of Project:
Damage to hair cells, the sensory cells of the inner ear, is the major cause of hearing loss as they do not regenerate in mammals. The transcription factor, Brn-3c, is known to be essential for hair cell survival and is thought to play a role in aiding hair cell repair throughout life. We are studying the targets of this transcription factor in order to determine which of these are responsible for the phenotype produced by loss of Brn-3c. The aim is to identify new genes responsible for hair cell survival, elucidate existing pathways and identify strategies for protecting and repairing hair cells.
Sud R, Jones CM, Banfi S, Dawson SJ. 2005. Transcriptional regulation by Barhl1 and Brn-3c in organ-of-Corti-derived cell lines. Brain Res Mol Brain Res. 141(2):174-80.