MBPhD Programme


SWANTON, R. Charles



Current Position:

PhD title:

Principal Supervisor:

Funding Source:

Description of Project:

Viral Cyclin Disruption of Mammalian Cell cycle Caontrol Mechanisms

PubMed-accessible Publications:

Marco Gerlinger, Andrew J. Rowan, Stuart Horswell, James Larkin, David Endesfelder, Eva Gronroos, Pierre Martinez, Nicholas Matthews, Aengus Stewart, Patrick Tarpey, Ignacio Varela, Benjamin Phillimore, Sharmin Begum, Neil Q. McDonald, Adam Butler, David Jones, Keiran Raine, Calli Latimer, Claudio R. Santos, Mahrokh Nohadani, Aron C. Eklund, Bradley Spencer-Dene, Graham Clark, Lisa Pickering, Gordon Stamp, Martin Gore, Zoltan Szallasi, Julian Downward, Andrew Futreal, and Charles Swanton, (2012)  Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing.  N Engl J Med 2012; 366:883-892

Swanton,C ., Mann,D.J., Fleckenstein,B., Neipel,F., Peters,G., & Jones,N. (1997) Herpes viral cyclin/Cdk6 complexes evade inhibition by CDK inhibitor proteins. Nature., 390, 184-187.

O'Neil,D., Swanton,C., Jones,A., Medd,P.G., Rayment,N., & Chain,B. (1999) IFN-gamma down-regulates MHC expression and antigen processing in a human B cell line. J.Immunol., 162, 791-798.

Mann,D.J., Child,E.S., Swanton,C., Laman,H., & Jones,N. (1999) Modulation of p27(Kip1) levels by the cyclin encoded by Kaposi's sarcoma-associated herpesvirus. EMBO J., 18, 654-663.

Swanton,C., Card,G.L., Mann,D., McDonald,N., & Jones,N. (1999) Overcoming inhibitions: subversion of CKI function by viral cyclins. Trends Biochem.Sci., 24, 116-120.

Cunliffe,D.R., Swanton,C., White,C., Watt-Smith,S.R., Cook,T.A., & George,B.D. (2000) Percutaneous endoscopic gastrostomy at the time of tumour resection in advanced oral cancer. Oral Oncol., 36, 471-473.

Swanton,C. & Jones,N. (2001) Strategies in subversion: de-regulation of the mammalian cell cycle by viral gene products. Int.J.Exp.Pathol., 82, 3-13.

Swanton,C. & Johnston,S. (2004) New Targets and Innovative Strategies in Cancer Treatment: one year of progress. 13-14 February 2004, Nice, France. IDrugs., 7, 306-311.

Swanton,C ., Nicke,B., & Downward,J. (2004) RNA interference, DNA methylation, and gene silencing: a bright future for cancer therapy? Lancet Oncol., 5, 653-654. Jones,R.L., Swanton,C., & Ewer,M.S. (2006) Anthracycline cardiotoxicity. Expert.Opin.Drug Saf., 5, 791-809.

Swanton,C . (2004) Cell-cycle targeted therapies. Lancet Oncol., 5, 27-36.

Swanton,C ., Tomlinson, I., & Downward,J. (2006) Chromosomal instability, colorectal cancer and taxane resistance. Cell Cycle., 5, 818-823.

Swanton,C ., Tomlinson, I., & Downward,J. (2006) Chromosomal instability, colorectal cancer and taxane resistance. Cell Cycle., 5, 818-823.

Swanton,C ., Futreal,A., & Eisen,T. (2006) Her2-targeted therapies in non-small cell lung cancer. Clin.Cancer Res., 12, 4377s-4383s.

Yau,T., Swanton,C., Chua,S., Sue,A., Walsh,G., Rostom,A., Johnston,S.R., O'Brien,M.E., & Smith,I.E. (2006) Incidence, pattern and timing of brain metastases among patients with advanced breast cancer treated with trastuzumab. Acta Oncol., 45, 196-201.

Ahmed,A.A., Mills,A.D., Ibrahim,A.E., Temple,J., Blenkiron,C., Vias,M., Massie,C.E., Iyer,N.G., McGeoch,A., Crawford,R., Nicke,B., Downward,J., Swanton,C., Bell,S.D., Earl,H.M., Laskey,R.A., Caldas,C., & Brenton,J.D. (2007) The Extracellular Matrix Protein TGFBI Induces Microtubule Stabilization and Sensitizes Ovarian Cancers to Paclitaxel. Cancer Cell., 12, 514-527.

Swanton,C ., Marani,M., Pardo,O., Warne,P.H., Kelly,G., Sahai,E., Elustondo,F., Chang,J., Temple,J., Ahmed,A.A., Brenton,J.D., Downward,J., & Nicke,B. (2007) Regulators of mitotic arrest and ceramide metabolism are determinants of sensitivity to paclitaxel and other chemotherapeutic drugs. Cancer Cell., 11, 498-512.

Swanton,C. , Nicke,B., Marani,M., Kelly,G., & Downward,J. (2007) Initiation of high frequency multi-drug resistance following kinase targeting by siRNAs. Cell Cycle., 6, 2001-2004.