(2020/21) PhD Research Year 4
Clinical, pathological and molecular characteristics of fatal childhood central nervous system tumours: a post-mortem study
Professor Thomas Jacques, UCL Great Ormond Street Institute of Child Health, Faculty of Population Health Sciences
Professor Neil Sebire, UCL Great Ormond Street Hospital for Children NHS Foundation Trust
Child Health Research Charitable Incorporated Organisation (CHR CIO) PhD Studentship
Description of PhD Project:
Central nervous system (CNS) tumours are the most common cause of childhood cancer deaths and often lead to life-changing and lifelong disability in the children who survive. We do not fully understand how these CNS tumours develop or why they stop responding to treatments. This means we cannot prevent these deaths.
Tissue from autopsy is a rare and invaluable resource that can help provide an insight into the biology of fatal CNS tumours and understand why these tumours become untreatable. I have assembled a cohort of fatal childhood CNS tumours from across the UK and am exploring the clinical, pathological and molecular aspects of these tumours. Specifically, I am assessing how the molecular profiles of fatal childhood CNS tumours change over time and across multiple infiltrated anatomical regions of the CNS. This will lead to a better understanding as to how advanced-stage CNS tumours can be treated, with the potential to develop novel therapies.
Smolicz I et al. Genetic alterations in advanced-stage paediatric central nervous system tumours: a next-generation sequencing study. 121st Meeting of the British Neuropathological Society, London, UK. March 2020.
Smolicz I et al. The biology of paediatric central nervous system tumours at post-mortem. 95th Annual Meeting of the American Association of Neuropathologists, Atlanta, Georgia, USA. June 2019.
Smolicz I et al. The biology of paediatric brain tumours at post-mortem: a national cohort. 120th Meeting of the British Neuropathological Society, London, UK. March 2019.