MBPhD Programme





Current Position:

Qualified 2002

PhD title:

Principal Supervisor:

Funding Source:

Description of Project:

The Role Map Kinases in the Regulation of Mechanical Load-Induced Procollagen Gene Expression in Cardiac Fibroblasts

PubMed-accessible Publications:

Dana,A., Skarli,M., Papakrivopoulou,J., & Yellon,D.M. (2000) Adenosine A(1) receptor induced delayed preconditioning in rabbits: induction of p38 mitogen-activated protein kinase activation and Hsp27 phosphorylation via a tyrosine kinase- and protein kinase C-dependent mechanism. Circ.Res., 86, 989-997.

Dabbagh,K., Laurent,G.J., Shock,A., Leoni,P., Papakrivopoulou,J., & Chambers,R.C. (2001) Alpha-1-antitrypsin stimulates fibroblast proliferation and procollagen production and activates classical MAP kinase signalling pathways. J.Cell Physiol., 186, 73-81.

Lindahl,G.E., Chambers,R.C., Papakrivopoulou,J., Dawson,S.J., Jacobsen,M.C., Bishop,J.E., & Laurent,G.J. (2002) Activation of fibroblast procollagen alpha 1(I) transcription by mechanical strain is transforming growth factor-beta-dependent and involves increased binding of CCAAT-binding factor (CBF/NF-Y) at the proximal promoter. J.Biol.Chem., 277, 6153-6161.

Papakrivopoulou,J. , Lindahl,G.E., Bishop,J.E., & Laurent,G.J. (2004) Differential roles of extracellular signal-regulated kinase 1/2 and p38MAPK in mechanical load-induced procollagen alpha1(I) gene expression in cardiac fibroblasts. Cardiovasc.Res., 61, 736-744.