MBPhD Programme


MANNION, Richard J



Current Position:

Qualified 2000

PhD title:

Principal Supervisor:

Funding Source:

Description of Project:

The Survival and Growth of Sensory neurone After Peripheral Nerve Injury

PubMed-accessible Publications:

Mannion,R.J ., Doubell,T.P., Coggeshall,R.E., & Woolf,C.J. (1996) Collateral sprouting of uninjured primary afferent A-fibers into the superficial dorsal horn of the adult rat spinal cord after topical capsaicin treatment to the sciatic nerve. J.Neurosci., 16, 5189-5195.

Doubell,T.P., Mannion,R.J., & Woolf,C.J. (1997) Intact sciatic myelinated primary afferent terminals collaterally sprout in the adult rat dorsal horn following section of a neighbouring peripheral nerve. J.Comp Neurol., 380, 95-104.

Mannion,R.J ., Doubell,T.P., Gill,H., & Woolf,C.J. (1998) Deafferentation is insufficient to induce sprouting of A-fibre central terminals in the rat dorsal horn. J.Comp Neurol., 393, 135-144.

Costigan,M., Mannion,R.J., Kendall,G., Lewis,S.E., Campagna,J.A., Coggeshall,R.E., Meridith-Middleton,J., Tate,S., & Woolf,C.J. (1998) Heat shock protein 27: developmental regulation and expression after peripheral nerve injury. J.Neurosci., 18, 5891-5900.

Woolf,C.J., Mannion,R.J., & Neumann,S. (1998) Null mutations lacking substance: elucidating pain mechanisms by genetic pharmacology. Neuron., 20, 1063-1066.

Tate,S., Benn,S., Hick,C., Trezise,D., John,V., Mannion,R.J., Costigan,M., Plumpton,C., Grose,D., Gladwell,Z., Kendall,G., Dale,K., Bountra,C., & Woolf,C.J. (1998) Two sodium channels contribute to the TTX-R sodium current in primary sensory neurons. Nat.Neurosci., 1, 653-655.

Mannion,R.J. , Costigan,M., Decosterd,I., Amaya,F., Ma,Q.P., Holstege,J.C., Ji,R.R., Acheson,A., Lindsay,R.M., Wilkinson,G.A., & Woolf,C.J. (1999) Neurotrophins: peripherally and centrally acting modulators of tactile stimulus-induced inflammatory pain hypersensitivity. Proc.Natl.Acad.Sci.U.S.A., 96, 9385-9390.

Lewis,S.E., Mannion,R.J., White,F.A., Coggeshall,R.E., Beggs,S., Costigan,M., Martin,J.L., Dillmann,W.H., & Woolf,C.J. (1999) A role for HSP27 in sensory neuron survival. J.Neurosci., 19, 8945-8953.

Woolf,C.J. & Mannion,R.J. (1999) Neuropathic pain: aetiology, symptoms, mechanisms, and management. Lancet., 353, 1959-1964.

Mannion,R.J. & Woolf,C.J. (2000) Pain mechanisms and management: a central perspective. Clin.J.Pain., 16, S144-S156.

Amaya,F., Decosterd,I., Samad,T.A., Plumpton,C., Tate,S., Mannion,R.J., Costigan,M., & Woolf,C.J. (2000) Diversity of expression of the sensory neuron-specific TTX-resistant voltage-gated sodium ion channels SNS and SNS2. Mol.Cell Neurosci., 15, 331-342.

Benn,S.C., Perrelet,D., Kato,A.C., Scholz,J., Decosterd,I., Mannion,R.J., Bakowska,J.C., & Woolf,C.J. (2002) Hsp27 upregulation and phosphorylation is required for injured sensory and motor neuron survival. Neuron., 36, 45-56.

Mannion,R . (2006) Neurosurgery-principles and practice. Br.J.Neurosurg., 20, 117.

Mannion,R.J ., Wilby,M., Godward,S., Lyratzopoulos,G., & Laing,R.J. (2007) The surgical management of metastatic spinal disease: prospective assessment and long-term follow-up. Br.J Neurosurg., 21, 593-598.

Mannion,R.J. , Cross,J., Bradley,P., Coles,J.P., Chatfield,D., Carpenter,A., Pickard,J.D., Menon,D.K., & Hutchinson,P.J. (2007) Mechanism-based MRI classification of traumatic brainstem injury and its relationship to outcome. J Neurotrauma., 24, 128-135.