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MBPhD Programme

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LEWIS, Martin Alexander

Entered:

2005

Current Position:

PhD title:

"Investigation and classification of novel cGMP binding proteins in the nervous system and their role in neuroprotection"

Principal Supervisor:

Prof John Garthwaite

Funding Source:

Emily Le Rossignol Foundation

Description of Project:

Superparamagnetic iron oxide (SPIO) nanoparticles are in current use as contrast agents in magnetic resonance imaging (MRI). It is also possible to label cells in vitro with these particles and image them using MRI both in vitro and in vivo, thus providing a means of tracking the fate of transplanted cells in animal models or humans. Because of the magnetic properties of SPIOs it is also possible to target them, together with the labelled cells, using an applied magnetic force. This project aims to label stem cells with SPIOs, in particular endothelial progenitor cells (EPCs), with the ultimate view of targeting them to a site of cardiovascular injury by using an externally applied magnetic field and visualising their adherence with MRI.

de Vries et al, Nat Biotechnol 2005 Nov;23(11):1407-13