"TGFBeta and FGF signalling in craniosynostosis."
Dr P Ferretti
Institute of Child Health (CHRAT)
Description of Project:
Craniosynostosis is a bone developmental defect due to abnormal fibroblast growth factor (FGF) signalling leading to premature suture fusion and varied skull dysmorphologies. Using a mouse in-vitro model with a known FGFR mutation, the bone regulation with transforming growth factor beta (TGFBeta) may have been impaired by expression of the mutant FGFR. The interaction of TGFBeta and FGF signalling was investigated in order find mechanisms that may underlie this disease.
J Exp Med. 2007 Mar 19;204(3):667-80