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MBPhD Programme

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KYRTATOS, Panagiotis

Entered:

2005
 

Current Position:

Qualified 2011

PhD title:

Targeted delivery and MRI tracking of magnetically labelled stem cells

Principal Supervisor:

Dr Mark Lithgow/Andrew Taylor, RCS Unit of Biophysics, Institute of Child Health
 

Funding Source:

Institute of Child Health (CHRAT)
 

Description of Project:

Superparamagnetic iron oxide (SPIO) nanoparticles are in current use as contrast agents in magnetic resonance imaging (MRI). It is also possible to label cells in vitro with these particles and image them using MRI both in vitro and in vivo, thus providing a means of tracking the fate of transplanted cells in animal models or humans. Because of the magnetic properties of SPIOs it is also possible to target them, together with the labelled cells, using an applied magnetic force. This project aims to label stem cells with SPIOs, in particular endothelial progenitor cells (EPCs), with the ultimate view of targeting them to a site of cardiovascular injury by using an externally applied magnetic field and visualising their adherence with MRI.

Winner of Cordwainers Prize 2009