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MBPhD Programme

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KAHAN, Joshua James

Entered:

July 2011

Current Position: 

Qualified: 2016

PhD title: 

Investigating the mechanism of action of Deep Brain Stimulation using functional Magnetic Resonance Imaging

Principal Supervisor: 

Dr Thomas Foltynie - Sobell Department of Motor Neuroscience and Movement Disorders

Funding Source: 

Rosetrees Charitable Trust , the Astor Foundation and the Middlesex Hospital Medical School General Charitable Trust

Description of Project:

Parkinson's disease (PD) is a neurodegenerative condition primarily affecting cells supplying the basal ganglia with dopamine. Clinically, this typically produces a classical pattern of motor symptoms, which deteriorate with disease progression. Deep brain stimulation (DBS) is surgical procedure involving the permanent implantation of a pacemaker and electrodes targeting deep brain structures. DBS has become an established means of managing advanced PD once medications alone fail to produce sufficient relief. Despite its increasing use, the mechanisms of action of DBS remain unclear. The purpose of my project is to gain more insight into the neuromodulatory nature of DBS using non-invasive functional magnetic resonance imaging in patients who have had the procedure. Specifically, I am interested in the effect of DBS on how distant brain regions communicate with each other. For this I work closely with the Unit of Functional Neurosurgery (supervised by Dr Tom Foltynie) and the Neuroradiology Academic Unit (Dr Laura Mancini, Prof. Xavier Golay) in the National Hospital for Neurology and Neurosurgery, Queen Square, as well as the Wellcome Trust Centre for Neuroimaging (Prof. Karl Friston).

 

Publications:

J. Kahan, M. Urner, R. Moran et al. (2014) Resting state functional MRI in Parkinson's disease: the impact of deep brain stimulation on 'effective' connectivity. In Brain. [link]

Karl J. Friston, Joshua Kahan, Bharat Biswal et al. (2013) A DCM for resting state fMRI. In NeuroImage. [link]

Tom Foltynie, Joshua Kahan (2013) Parkinson's disease: an update on pathogenesis and treatment., 1433-40. In Journal of neurology 260 (5). [link]

Joshua Kahan, Zinovia Kefalopoulou, James Gratwicke et al. (2013) Sodium oxybate as a treatment for DBS-resistant, alcohol-responsive post-anoxic myoclonus., e2. In Journal of neurology, neurosurgery, and psychiatry 84 (11). [link]

James Gratwicke, Joshua Kahan, Ludvic Zrinzo et al. (2013) The nucleus basalis of Meynert: A new target for deep brain stimulation in dementia?, 2676-88. In Neuroscience and biobehavioral reviews 37 (10 Pt 2). [link]

Joshua Kahan, Tom Foltynie (2013) Understanding DCM: Ten simple rules for the clinician., 542-549. In NeuroImage. [link]

Josh Kahan, Laura Mancini, Maren Urner et al. (2012) Therapeutic subthalamic nucleus deep brain stimulation reverses cortico-thalamic coupling during voluntary movements in Parkinson's disease., e50270. In PloS one 7 (12). [link]

Tessel Boertien, Ludvic Zrinzo, Joshua Kahan et al. (2011) Functional imaging of subthalamic nucleus deep brain stimulation in Parkinson's disease., 1835-43. In Movement disorders: official journal of the Movement Disorder Society 26 (10). [link]

Teaching:

Statistical Parametric Mapping Course - October 2013

Awards & Prizes: