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HEUKAMP, Lukas C

Entered:

1995

Current Position:

Qualified 2001

PhD title:

Principal Supervisor:


Funding Source:

Description of Project:

Cellular Immune Responses Against the Tumour Associated Polymorphic Epithelial Mucin Mucl.

PubMed-accessible Publications:

van Hall,T., van Bergen,J., van Veelen,P.A., Kraakman,M., Heukamp,L.C., Koning,F., Melief,C.J., Ossendorp,F., & Offringa,R. (2000) Identification of a novel tumor-specific CTL epitope presented by RMA, EL-4, and MBL-2 lymphomas reveals their common origin. J.Immunol., 165, 869-877.

Heukamp,L.C. , van der Burg,S.H., Drijfhout,J.W., Melief,C.J., Taylor-Papadimitriou,J., & Offringa,R. (2001) Identification of three non-VNTR MUC1-derived HLA-A*0201-restricted T-cell epitopes that induce protective anti-tumor immunity in HLA-A2/K(b)-transgenic mice. Int.J.Cancer., 91, 385-392.

Heukamp,L.C. , van Hall,T., Ossendorp,F., Burchell,J.M., Melief,C.J., Taylor-Papadimitriou,J., & Offringa,R. (2002) Effective immunotherapy of cancer in MUC1-transgenic mice using clonal cytotoxic T lymphocytes directed against an immunodominant MUC1 epitope. J.Immunother., 25, 46-56.

Heukamp,L.C. , Schroder,D.W., Plassmann,D., Homann,J., & Buttner,R. (2003) Marked clinical and histologic improvement in a patient with type-1 Gaucher's disease following long-term glucocerebroside substitution. A case report and review of current diagnosis and management. Pathol.Res.Pract., 199, 159-163.

Bastian,P.J., Ellinger,J., Wellmann,A., Wernert,N., Heukamp,L.C., Muller,S.C., & von Ruecker,A. (2005) Diagnostic and prognostic information in prostate cancer with the help of a small set of hypermethylated gene loci. Clin.Cancer Res., 11, 4097-4106.

Pauls,K., Wardelmann,E., Franke,F.E., Heukamp,L., Buttner,R., Mey,U., & Zhou,H. (2005) Primary extragonadal germ cell tumour: unusual localization of a c-kit mutated retroperitoneal seminoma in the gastric wall. Histopathology., 47, 112-114.

Bastian,P.J., Ellinger,J., Wellmann,A., Wernert,N., Heukamp,L.C., Muller,S.C., & von,R.A. (2005) Diagnostic and prognostic information in prostate cancer with the help of a small set of hypermethylated gene loci. Clin.Cancer Res., 11, 4097-4106.

Heukamp,L.C. , Fischer,H.P., Schirmacher,P., Chen,X., Breuhahn,K., Nicolay,C., Buttner,R., & Gutgemann,I. (2006) Podocalyxin-like protein 1 expression in primary hepatic tumours and tumour-like lesions. Histopathology., 49, 242-247.

Kahl,P., Gullotti,L., Heukamp,L.C., Wolf,S., Friedrichs,N., Vorreuther,R., Solleder,G., Bastian,P.J., Ellinger,J., Metzger,E., Schule,R., & Buettner,R. (2006) Androgen receptor coactivators lysine-specific histone demethylase 1 and four and a half LIM domain protein 2 predict risk of prostate cancer recurrence. Cancer Res., 66, 11341-11347

Tormo,D., Ferrer,A., Gaffal,E., Wenzel,J., Basner-Tschakarjan,E., Steitz,J., Heukamp,L.C., Gutgemann,I., Buettner,R., Malumbres,M., Barbacid,M., Merlino,G., & Tuting,T. (2006) Rapid growth of invasive metastatic melanoma in carcinogen-treated hepatocyte growth factor/scatter factor-transgenic mice carrying an oncogenic CDK4 mutation. Am.J Pathol., 169, 665-672.

Bastian,P.J., Ellinger,J., Heukamp,L.C., Kahl,P., Muller,S.C., & von,R.A. (2007) Prognostic value of CpG island hypermethylation at PTGS2, RAR-beta, EDNRB, and other gene loci in patients undergoing radical prostatectomy. Eur.Urol., 51, 665-674.

Kahl,P., Heukamp,L.C., Buettner,R., Friedrichs,N., Roesing,B., & Knopfle,G. (2007) Orofaciodigital syndrome type IV (Mohr-Majewski syndrome): report of a family with two affected siblings. Pediatr.Dev.Pathol., 10, 239-243.

Omisanjo,O.A., Biermann,K., Hartmann,S., Heukamp,L.C., Sonnack,V., Hild,A., Brehm,R., Bergmann,M., Weidner,W., & Steger,K. (2007) DNMT1 and HDAC1 gene expression in impaired spermatogenesis and testicular cancer. Histochem.Cell Biol., 127, 175-181.

Biermann,K., Heukamp,L.C., Steger,K., Zhou,H., Franke,F.E., Guetgemann,I., Sonnack,V., Brehm,R., Berg,J., Bastian,P.J., Muller,S.C., Wang-Eckert,L., Schorle,H., & Buttner,R. (2007) Gene expression profiling identifies new biological markers of neoplastic germ cells. Anticancer Res., 27, 3091-3100.

Poepel,A., Jarius,S., Heukamp,L.C., Urbach,H., Elger,C.E., Bien,C.G., & Voltz,R. (2007) Neurological course of long-term surviving patients with SCLC and anti-Hu syndrome. J Neurol.Sci., 263, 145-148.

Walgenbach-Brunagel,G., Burger,B., Leman,E.S., Walgenbach,K.J., Tolba,R., Heukamp,L., Hirner,A., & Getzenberg,R.H. (2007) The use of a colon cancer associated nuclear antigen CCSA-2 for the blood based detection of colon cancer. J Cell Biochem., .

Eckert,D., Nettersheim,D., Heukamp,L.C., Kitazawa,S., Biermann,K., & Schorle,H. (2007) TCam-2 but not JKT-1 cells resemble seminoma in cell culture. Cell Tissue Res., .

Heukamp,L.C ., Knoblich,A., Rausch,E., Friedrichs,N., Schildhaus,H.U., Kahl,P., Tismer,R., Schneider,B., Buttner,R., & Houshdaran,F. (2007) Extraosseous osteosarcoma arising from the small intestinal mesentery. Pathol.Res.Pract., 203, 473-477.

Biermann,K., Heukamp,L.C., Buttner,R., & Zhou,H. (2008) Uterine tumor resembling an ovarian sex cord tumor associated with metastasis. Int.J Gynecol.Pathol., 27, 58-60.

Ellinger,J., Haan,K., Heukamp,L.C., Kahl,P., Buttner,R., Muller,S.C., von,R.A., & Bastian,P.J. (2008) CpG Island hypermethylation in cell-free serum DNA identifies patients with localized prostate cancer. Prostate., 68, 42-49.

Ellinger,J., El,K.N., Heukamp,L.C., Matthews,S., Cubukluoz,F., Kahl,P., Perabo,F.G., Muller,S.C., von,R.A., & Bastian,P.J. (2008) Hypermethylation of cell-free serum DNA indicates worse outcome in patients with bladder cancer. J Urol., 179, 346-352.

Ellinger,J., Bastian,P.J., Haan,K.I., Heukamp,L.C., Buettner,R., Fimmers,R., Mueller, S.C., & von,R.A. (2008) Noncancerous PTGS2 DNA fragments of apoptotic origin in sera of prostate cancer patients qualify as diagnostic and prognostic indicators. Int.J Cancer., 122, 138-143.

Schulte,J.H., Horn,S., Otto,T., Samans,B., Heukamp,L.C., Eilers,U.C., Krause,M., Astrahantseff,K., Klein-Hitpass,L., Buettner,R., Schramm,A., Christiansen,H., Eilers,M., Eggert,A., & Berwanger,B. (2008) MYCN regulates oncogenic MicroRNAs in neuroblastoma. Int.J Cancer., 122, 699-704.