MBPhD Programme


BURRELL, Rebecca Alison



Current Position:

Qualified: 2015

PhD title:

Replication stress links structural and numerical chromosomal instability in colorectal cancer

Principal Supervisor:

Prof Charles Swanton - Cancer Research UK, LRI

Funding Source:

Cancer Research UK

Description of Project:

Using functional genomics to understand chromosomal instability


Burrell RA, McGranahan N, Bartek J, Swanton C. The causes and consequences of
genetic heterogeneity in cancer evolution. Nature. 2013 Sep 19;501(7467):338-45.
doi: 10.1038/nature12625.

Martinez P, Birkbak NJ, Gerlinger M, McGranahan N, Burrell RA, Rowan AJ, Joshi T, Fisher R, Larkin J, Szallasi Z, Swanton C. Parallel evolution of tumour
subclones mimics diversity between tumours. J Pathol. 2013 Aug;230(4):356-64. doi: 10.1002/path.4214.

Burrell RA, McClelland SE, Endesfelder D, Groth P, Weller MC, Shaikh N, Domingo E, Kanu N, Dewhurst SM, Gronroos E, Chew SK, Rowan AJ, Schenk A, Sheffer  M, Howell M, Kschischo M, Behrens A, Helleday T, Bartek J, Tomlinson IP, Swanton C. Replication stress links structural and numerical cancer chromosomal instability. Nature. 2013 Feb 28;494(7438):492-6. doi: 10.1038/nature11935. Erratum in: Nature. 2013 Aug 22;500(7463):490.

McGranahan N, Burrell RA, Endesfelder D, Novelli MR, Swanton C. Cancer chromosomal instability: therapeutic and diagnostic challenges. EMBO Rep. 2012
Jun 1;13(6):528-38. doi: 10.1038/embor.2012.61. Review.

Gerlinger M, Santos CR, Spencer-Dene B, Martinez P, Endesfelder D, Burrell RA, Vetter M, Jiang M, Saunders RE, Kelly G, Dykema K, Rioux-Leclercq N, Stamp G,
Patard JJ, Larkin J, Howell M, Swanton C. Genome-wide RNA interference analysis of renal carcinoma survival regulators identifies MCT4 as a Warburg effect
metabolic target. J Pathol. 2012 Jun;227(2):146-56. doi: 10.1002/path.4006. Epub 2012 Apr 18. PubMed PMID: 22362593;

Roylance R, Endesfelder D, Gorman P, Burrell RA, Sander J, Tomlinson I, Hanby AM, Speirs V, Richardson AL, Birkbak NJ, Eklund AC, Downward J, Kschischo M,
Szallasi Z, Swanton C. Relationship of extreme chromosomal instability with long-term survival in a retrospective analysis of primary breast cancer. Cancer Epidemiol Biomarkers Prev. 2011 Oct;20(10):2183-94. doi: 10.1158/1055-9965.EPI-11-0343. Epub 2011 Jul 22.

Swanton C, Burrell RA, Futreal PA. Breast cancer genome heterogeneity: a challenge to personalised medicine? Breast Cancer Res. 2011 Feb 1;13(1):104. doi:
10.1186/bcr2807. PubMed PMID: 21345264;

Burrell RA, Juul N, Johnston SR, Reis-Filho JS, Szallasi Z, Swanton C. Targeting chromosomal instability and tumour heterogeneity in HER2-positive
breast cancer. J Cell Biochem. 2010 Nov 1;111(4):782-90. doi: 10.1002/jcb.22781. Review.

Juul N, Szallasi Z, Eklund AC, Li Q, Burrell RA, Gerlinger M, Valero V, Andreopoulou E, Esteva FJ, Symmans WF, Desmedt C, Haibe-Kains B, Sotiriou C, Pusztai L, Swanton C. Assessment of an RNA interference screen-derived mitotic and ceramide pathway metagene as a predictor of response to neoadjuvant paclitaxel for primary triple-negative breast cancer: a retrospective analysis of five clinical trials. Lancet Oncol. 2010 Apr;11(4):358-65. doi: 10.1016/S1470-2045(10)70018-8. Epub 2010 Feb 26.

Swanton C, Burrell RA. Advances in personalized therapeutics in non-small cell lung cancer: 4q12 amplification, PDGFRA oncogene addiction and sunitinib
sensitivity. Cancer Biol Ther. 2009 Nov;8(21):2051-3.

McClelland SE, Burrell RA, Swanton C. Chromosomal instability: a composite phenotype that influences sensitivity to chemotherapy. Cell Cycle. 2009 Oct
15;8(20):3262-6. Epub 2009 Oct 31. Review.