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PhD Studentship - Developing a digital twin of 3D vascular systems

UCL Department / Division: Mathematics
Location of position: London
Studentship Start Date: 1st February 2025
Duration of Studentship: 4 Years
Stipend: Approximately £21,237 pa. 
Tuition Fees: UK Tuition Fee rate covered by the studentship. International applications are welcome to apply but will need to cover the international tuition fee balance themselves.

** Closing date: Sunday 15th December 2024 **

Vacancy Information
Applications are invited for a PhD funding opportunity in the UCL Department of Mathematics starting on 1st February 2025. This project is fully funded project by the NC3Rs research council on Developing a digital twin of 3D vascular systems to study haemorrhagic viral diseases. Successful candidates will be admitted to the MPhil/PhD programme in Mathematics.
For further information on applying to the programme see:
https://www.ucl.ac.uk/maths/study/mphilphd-mathematics.

Interested applicants should contact Dr Carina Dunlop (carina.dunlop@ucl.ac.uk) in the first instance.

Studentship Description
The project will develop a digital twin of an experimental 3D microvascular organoid culture system working in collaboration with Dr Paola Campagnolo (School of Biosciences, University of Surrey).   Specifically, individual-based computational simulations will be used  to investigate the role of mechanical interactions between cells in haemorrhagic disease. The digital twin will be an accurate biological mimic that is user-friendly within an experimental context; optimised for co-culture microvascular organoids. The combined digital twin and experimental organoid system will constitute a powerful tool for investigating new treatments for these severe diseases without the use of animal models. The student will also spend time in the lab of the experimental collaborator (Campagnolo lab), learning wet-lab techniques and performing experiments that will contribute to data collection for the simulations.

Person Specification
Applicants should possess a a Masters level degree in Mathematics, Physics or Computer Science or similar physical sciences/bioengineering backgrounds, or an equivalent qualification from other countries. An essential criterion is a willingness to engage with biological detail.

Application Process
1) First contact Dr Carina Dunlop (carina.dunlop@ucl.ac.uk) to discuss the project and your suitability for the project.

2) Apply for the MPhil/PhD programme in Mathematics at UCL, 2024/25 entry, by completing the UCL Postgraduate Application on-line form available at: https://www.ucl.ac.uk/prospective-students/graduate/apply
Your proposed supervisor(s) should be entered on the form in the indicated field.

3) Fill in the following Equality and Diversity form: https://forms.office.com/e/ZN2WDihKkR
This is for monitoring purposes only and will not affect your application.

Closing date: Sunday 15th December 2024
Interviews will be held online or in person as soon as possible.