Seminar: How cells exploit their shape during collective cell decisions and migration
06 December 2022, 11:00 am–12:00 pm

I will show some of our recent integrated predictive simulation and in vivo work focussed on understanding how cells coordinate during angiogenesis and neural crest collective migration
This event is free.
Event Information
Open to
- All
Availability
- Yes
Cost
- Free
Organiser
-
Philip Pearce
Location
-
Lankester Lecture TheatreUniversity College London, Malet PlLondonWC1E 6BT
UCL-Crick Mathematical Biology Meeting:
Speaker: Katie Bentley (Francis Crick Institute)
Cells change shape, often to take on quite dramatically different forms while they move and interact. I will show some of our recent integrated predictive simulation and in vivo work focussed on understanding how cells coordinate during angiogenesis and neural crest collective migration, which predicts that the cells ability to adaptively change shape, which in turns feedback to alter their interactions, signalling and/or notch decisions lie at the heart of robust and timely collective migration and decision-making.
Relevant papers:
1. Zakirov et al Active perception during angiogenesis: filopodia speed up Notch selection of tip cells in silico and in vivo. Royal society PTB 2021 :
2. Alhashem et al Notch controls the cell cycle to define leader versus follower identities during collective cell migration e Life 2022
3. (perspectives piece on our embodied agent based modelling approach) Bentley et al. Do Endothelial cells dream of eclectic shape? Dev Cell 2014: