IPLS/BioP Seminar: Dr. Silke Henkes (University of Bristol)

Abstract: Epithelial cell sheets form a fundamental role in the developing embryo, and also in adult tissues including the gut and the cornea of the eye. Soft and active matter provides a theoretical and computational framework to understand the mechanics and dynamics of these tissues. First, I will show, using both particle and vertex models, how the extended ’swirly’ velocity fluctuations seen in sheets on a substrate can be understood using a simple model that couples linear elasticity with disordered activity. We are able to quantitatively match experiments using in-vitro corneal epithelial cells. I will conclude by showing preliminary results for a model where active contractility arises from a myosin-tension feedback loop on individual junctions.