Publications

The Facility Publications

  1. Non-invasive in vivo sensing of bacterial implant infection using catalytically-optimised gold nanocluster-loaded liposomes for urinary readout,  Molly Stevens, Kaili Chen, Adrian Najer, Patrick Charchar, Catherine Saunders, Chalaisorn Thanapongpibul, Anna Klöckner, Mohamed Chami, David Peeler, Inês Silva, Luca Panariello, Kersti Karu, Colleen Loynachan, Leah Frenette, Michael Potter, John Tregoning, Ivan Parkin, Andrew Edwards, Thomas Clarke, Irene Yarovsky, Nature Communications volume 15, Article number: 10321 (2024), https://doi.org/10.1038/s41467-024-53537-2
  2. Phytosterols in human serum as measured using a liquid chromatography tandem mass spectrometry, Yu Chun Teng, Marie Claire Gielen, Nina M de Gruijter, Coziana Ciurtin, Elizabeth C. Rosser, Kersti Karu, Journal of Steroid Biochemistry and Molecular Biology, Vol. 241, July 2024, 106519. https://www.sciencedirect.com/science/article/pii/S0960076024000670
  3. Antibiotic Residues in UK Foods: Exploring the Exposure Pathways and Associated Health Risks - PubMed (nih.gov), Jegak Seo, Frank Kloprogge, Andrew M Smith, Kersti Karu, Lena Ciric, Toxic, 2024, Feb 24, 12(3), 174.
  4. Two-substrate enzyme engineering using small libraries that combine the substrate preferences from two different variant lineages. Mukhopadhyay A, Karu K, Dalby PA.Sci Rep. 2024 Jan 14;14(1):1287. doi: 10.1038/s41598-024-51831-z.PMID: 38218974 
  5. The Nitrile Bis-Thiol Bioconjugation Reaction. Patel M, Forte N, Bishop CR, Porter MJ, Dagwell M, Karu K, Chudasama V, Baker JR.J Am Chem Soc. 2024 Jan 10;146(1):274-280. doi: 10.1021/jacs.3c08762. Epub 2023 Dec 20.PMID: 38124442 
  6. Antibiotic resistance genes and the association with bacterial community in biofilms occurring during the drinking water granular activated carbon (GAC) sandwich biofiltration. Xu L, Canales M, Zhou Q, Karu K, Zhou X, Su J, Campos LC, Ciric L.J Hazard Mater. 2023 Oct 15;460:132511. doi: 10.1016/j.jhazmat.2023.132511. Epub 2023 Sep 9.PMID: 37708648 
  7. Antibacterial Properties of Honey Nanocomposite Fibrous Meshes. Matharu RK, Ahmed J, Seo J, Karu K, Golshan MA, Edirisinghe M, Ciric L.Polymers (Basel). 2022 Nov 27;14(23):5155. doi: 10.3390/polym14235155.PMID: 36501550 
  8. Unearthing the unique stability of thiophosphonium-C-terminal cysteine adducts on peptides and proteins. Spears RJ, Chrzastek A, Yap SY, Karu K, Aliev AE, Baker JR, Chudasama V.Chem Commun (Camb). 2022 Apr 28;58(35):5359-5362. doi: 10.1039/d2cc01090a.PMID: 35394478
  9. Identification of diverse lipid-binding modes in the groove of zinc α2 glycoprotein reveals its functional versatility. Zahid H, Lau AM, Kelly SM, Karu K, Gor J, Perkins SJ, McDermott LC.FEBS J. 2022 Apr;289(7):1876-1896. doi: 10.1111/febs.16293. Epub 2021 Dec 7.PMID: 34817923 
  10. Probing cytochrome P450 (CYP) bioactivation with chloromethylindoline bioprecursors derived from the duocarmycin family of compounds. Ortuzar N, Karu K, Presa D, Morais GR, Sheldrake HM, Shnyder SD, Barnieh FM, Loadman PM, Patterson LH, Pors K, Searcey M.Bioorg Med Chem. 2021 Jun 15;40:116167. doi: 10.1016/j.bmc.2021.116167. Epub 2021 Apr 21.PMID: 33932713
  11. Optimisation of the dibromomaleimide (DBM) platform for native antibody conjugation by accelerated post-conjugation hydrolysis. Morais M, Nunes JPM, Karu K, Forte N, Benni I, Smith MEB, Caddick S, Chudasama V, Baker JR.Org Biomol Chem. 2021 Apr 7;19(13):3024. doi: 10.1039/d1ob90035h. Epub 2021 Mar 24.PMID: 33885556
  12. Simultaneous measurement of free and conjugated estrogens in surface water using capillary liquid chromatography tandem mass spectrometry. Huang F, Karu K, Campos LC.Analyst. 2021 Apr 26;146(8):2689-2704. doi: 10.1039/d0an02335c.PMID: 33751008
  13. Removal of antibiotics in sand, GAC, GAC sandwich and anthracite/sand biofiltration systems. Xu L, Campos LC, Li J, Karu K, Ciric L.Chemosphere. 2021 Jul;275:130004. doi: 10.1016/j.chemosphere.2021.130004. Epub 2021 Feb 17.PMID: 33640744
  14. Continuous Single-Phase Synthesis of [Au25(Cys)18] Nanoclusters and their Photobactericidal Enhancement. Hwang GB, Wu G, Shin J, Panariello L, Sebastian V, Karu K, Allan E, Gavriilidis A, Parkin IP.ACS Appl Mater Interfaces. 2020 Oct 28;12(43):49021-49029. doi: 10.1021/acsami.0c07691. Epub 2020 Oct 19.PMID: 33073567
  15. Cysteine-to-lysine transfer antibody fragment conjugation.Forte N, Benni I, Karu K, Chudasama V, Baker JR.Chem Sci. 2019 Oct 11;10(47):10919-10924. doi: 10.1039/c9sc03825f. eCollection 2019 Dec 21.PMID: 32190247 Free PMC article.
  16. Photobactericidal activity activated by thiolated gold nanoclusters at low flux levels of white light. Hwang GB, Huang H, Wu G, Shin J, Kafizas A, Karu K, Toit HD, Alotaibi AM, Mohammad-Hadi L, Allan E, MacRobert AJ, Gavriilidis A, Parkin IP. Nat Commun. 2020 Mar 5;11(1):1207. doi: 10.1038/s41467-020-15004-6.PMID: 32139700 Free
  17. Quantitative Proteomic Analysis of the Central Amygdala in Neuropathic Pain Model Rats. Karu K, Swanwick RS, Novejarque-Gadea A, Antunes-Martins A, Thomas B, Yoshimi E, Foster W, Fang M, McMahon SB, Bennett DLH, Rice ASC, Okuse K.J Proteome Res. 2020 Apr 3;19(4):1592-1619. doi: 10.1021/acs.jproteome.9b00805. Epub 2020 Mar 3.PMID: 32050077
  18. Optimised approach to albumin-drug conjugates using monobromomaleimide-C-2 linkers. Wall A, Nicholls K, Caspersen MB, Skrivergaard S, Howard KA, Karu K, Chudasama V, Baker JR.Org Biomol Chem. 2019 Aug 28;17(34):7870-7873. doi: 10.1039/c9ob00721k.PMID: 31410415
  19. LC-MS analysis to determine the biodistribution of a polymer coated ilomastat ocular implant. Mohamed-Ahmed AHA, Lockwood A, Fadda H, Madaan S, Khaw PT, Brocchini S, Karu K.J Pharm Biomed Anal. 2018 Aug 5;157:100-106. doi: 10.1016/j.jpba.2018.05.017. Epub 2018 May 17.PMID: 29777984
  20. Effect of Flavin-Containing Monooxygenase Genotype, Mouse Strain, and Gender on Trimethylamine N-oxide Production, Plasma Cholesterol Concentration, and an Index of Atherosclerosis. Veeravalli S, Karu K, Scott F, Fennema D, Phillips IR, Shephard EA.Drug Metab Dispos. 2018 Jan;46(1):20-25. doi: 10.1124/dmd.117.077636. Epub 2017 Oct 25.PMID: 29070510 Free PMC article.
  21. A highly sensitive liquid chromatography electrospray ionization mass spectrometry method for quantification of TMA, TMAO and creatinine in mouse urine. Veeravalli S, Karu K, Phillips IR, Shephard EA.MethodsX. 2017 Sep 28;4:310-319. doi: 10.1016/j.mex.2017.09.004. eCollection 2017.PMID: 29062719 Free PMC article.
  22. Optimisation of the dibromomaleimide (DBM) platform for native antibody conjugation by accelerated post-conjugation hydrolysis. Morais M, Nunes JPM, Karu K, Forte N, Benni I, Smith MEB, Caddick S, Chudasama V, Baker JR.Org Biomol Chem. 2017 Apr 5;15(14):2947-2952. doi: 10.1039/c7ob00220c.PMID: 28290574
  23. Influence of PPCPs on the performance of intermittently operated slow sand filters for household water purification. Pompei CME, Ciric L, Canales M, Karu K, Vieira EM, Campos LC.Sci Total Environ. 2017 Mar 1;581-582:174-185. doi: 10.1016/j.scitotenv.2016.12.091. Epub 2016 Dec 29.PMID: 28041695
  24. The structure of tagetitoxin. Aliev AE, Karu K, Mitchell RE, Porter MJ.Aliev AE, Org Biomol Chem. 2016 Jan 7;14(1):238-45.
  25. Analysis of transferred fragrance and its forensic implications, Gherghel S, Morgan RM, Blackman CS, Karu K, Parkin IP., Sci Justice. 2016 Dec;56(6):413-420.
  26. The spatial distribution patterns of condensed phase post-blast explosive residues formed during detonation, Abdul-Karim N, Blackman CS, Gill PP, Karu K., J Hazard Mater. 2016 Oct 5;316:204-13.
  27. Covalent Bonding of Pyrrolobenzodiazepines (PBDs) to Terminal Guanine Residues within Duplex and Hairpin DNA Fragments. Mantaj J, Jackson PJ, Karu K, Rahman KM, Thurston DE. PLoS One. 2016 Apr 7;11(4)
  28. Peptoidosomes as nanoparticles from amphiphilic block alpha-peptoids using solid-phase-synthesis, J Gaitzsch, K Karu, G Battaglia, European Polymer Journal, Volume 73, December 2015, 447–454
  29. A clinically relevant rodent model of the HIV antiretroviral drug stavudine induced painful peripheral neuropathy. Huang W, Calvo M, Karu K, Olausen HR, Bathgate G, Okuse K, Bennett DL, Rice AS.Huang W, Pain. 2013 Apr;154(4):560-75.
  30. Identification of a receptor for neuropeptide VGF and its role in neuropathic pain. Chen YC, Pristerá A, Ayub M, Swanwick RS, Karu K, Hamada Y, Rice AS, Okuse K.Chen YC, J Biol Chem. 2013 Nov 29;288(48):34638-4
  31. Identification of novel brain endogenous Liver X Receptor ligands that selectively promote red nucleus or midbrain dopamine neurogenesis, Theofilopoulos S,  Wang Y, Kitambi S, Sacchetti P,Sousa K M, Bodin K, Kirk J, Gustafsson M, Karu K, Ernfors P, Sjövall J, Griffiths J W,  Arenas E, Nature Chemical Biology, 2013 Feb;9(2):126-33
  32. A clinically relevant rodent model of the HIV antiretroviral drug stavudine induced painful peripheral neuropathy. Huang W, Calvo M, Karu K, Olausen HR, Bathgate G, Okuse K, Bennett DL, Rice AS., Pain. 2013 Apr;154(4):560-75
  33. Nano-liquid chromatography-tandem mass spectrometry analysis of oxysterols in brain: monitoring of cholesterol autoxidation, Karu K, Turton J, Wang Y, Griffiths WJ. Chem Phys Lipids. 2011 Sep;164(6):411-24. Epub 2011 May 6.
  34. Relative quantification of polyethylene glycol 400 excreted in the urine of male and female volunteers by direct injection electrospray-selected ion monitoring mass spectrometry, Ashiru D, Karu K, Basit A, M Zloh, Int J Pharm. 2011 Jul 29;414(1-2):35-41. Epub 2011 Apr 30.
  35. Induction of the cytoprotective enzyme heme oxygenase-1 by statins is enhanced in vascular endothelium exposed to laminar shear stress and impaired by disturbed flow, Ali F, Zakkar M, Karu K, Lidington EA, Hamdulay SS, Boyle JJ, Zloh M, Bauer A, Haskard DO, Evans PC, Mason JC., J Biol Chem. 2009 Jul 10;284(28):18882-92. Epub 2009 May 19.
  36. T-cadinol nerolidol ether from Schisandra chinensis. Patel, A.V., Blunden, G., Cary, P.D., Opletal, L., Berankova, M., Karu, K., Thurston, D.E. and Pour, M. (2008) Natural Product Communications, 3 . pp. 1453-1456.
  37. Targeted lipidomic analysis of oxysterols in the embryonic central nervous system, Y. Wang, K. M. Sousa, K. Bodin, S.Theofilopoulos, P.Sacchetti, M. Hornshaw, G. Woffendin, K. Karu, J. Sjövall, E. Arenas, W. J. Griffiths,   Mol Biosyst. 2009 May;5(5):529-41. Epub 2009 Mar 27.
  38. Potential of sterol analysis by liquid chromatography - tandem mass spectrometry for the prenatal diagnosis of Smith-Lemli-Opitz syndrome, W. J. Griffiths, Y. Wang, K. Karu, E. Samuel, S. McDonnell, M. Hornshaw, C. Shackleton, Clinical Chemistry, August 2008, Vol. 54, Issue 7, 1317-1324.
  39. Liquid Chromatography Combined with Mass Spectrometry Utilising High-Resolution, Exact Mass, and Multi-Stage Fragmentation for the Identification of Oxysterols in Rat Brain, K. Karu, M. Hornshaw, G. Woffendin, K. Bodin, M. Hamberg, G. Alvelius, J. Sjövall,  J. Turton, Y. Wang and W.J. Griffiths, Journal of Lipid Research, April 2007, Vol. 48, Issue 4, 976- 987.
  40. Metabolomics and metabolite profiling: past heroes and future developments, W.J. Griffiths, K. Karu, M. Hornshaw,  G. Woffendin, Y. Wang, European Journal Mass Spectrometry, 2007, 13, 45-50.
  41. Analysis of neurosterols and neurosteroids by mass spectrometry, Y. Wang, K. Karu and W. J. Griffiths, Biochemie, February 2007, Vol. 89, Issue 2, 182-191.
  42. C. Lane, K. Karu, C. Seibert, W.J. Griffiths, L.H. Patterson, 2005, Molecular Cell Proteomics, 4, (Suppl. 8), 5481.

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