I am mainly interested in how membrane lipids play key roles in autophagy, which is accompanied by membrane remodeling. After discovery of autophagy-related (ATG) genes, the molecular machinery of autophagy is becoming clear. However, the roles of membrane lipids are not well understood mainly due to technical difficulties. I would like to redescribe autophagy from lipid aspects by in vitro (liposome reconstitution experiments) and in vivo experiments (using super-resolution microscope). It is known that imbalance in lipid homeostasis can cause autophagy-related diseases. Therefore, I believe that the precise understanding of lipid function in autophagy will be also helpful for understanding the pathogenesis of those diseases.
Japan Society for the Promotion of Science
Signalling pathways, Membrane trafficking
Light microsopy, Super-resolution microscopy