Research synopsis
I joined the LMCB in September 2015 as part of the graduate programme and I’m carrying out my PhD in the de Bruin lab. In my project I am using budding yeast as a model to study transcriptional regulation during the cell cycle. Proper cell cycle progression requires tightly regulated transcriptional events, and I am particularly interested in the role of chromatin within this. I am investigating the relationship between transcription and DNA replication during S phase and I am interested in how this regulation may be important for genomic integrity. Additionally, I am studying the control of G1/S transcription and the transcription factors implicated in this. This transcriptional wave drives entry into a new cell cycle and must be tightly regulated to control cell proliferation.
Biography
2015 | BSc (Hons) Biochemistry with Research Abroad, Imperial College London
Awards
2016 | UCSF Scholarship – LMCB PhD programme
2015 | Convenor’s Prize – Imperial College London
Funders
Medical Research Council
Research themes
Transcriptional regulation, Cell cycle
Technology
Light microscopy, Bioinformatics