Poxviruses possess a complex fusion machinery with 11 different proteins individually required for fusion. Very little is known about the specific roles of these proteins and why so many different proteins are required for fusion remains an enigma. My project aims to provide insight into the entry-fusion mechanism of the prototypic poxvirus, vaccinia, by carrying out structure-function analyses of the entry-fusion proteins. Additionally, I would like to understand vaccinia morphogenesis in greater detail using correlative super-resolution fluorescence and electron microscopy. Such knowledge will increase our understanding of the poxvirus membrane fusion mechanism in addition to facilitating the development of future vaccines and anti-viral agents.
2015 | BSc Biochemistry with a year in industry, University of York, UK
2013-2014 | Research placement St. Vincent’s Institute of Medical Research, Melbourne, Australia
Medical Research Council
Membrane trafficking, Viral pathogens
Light microscopy, Electron microscopy, Super-resolution microscopy