The Gissen Lab was set up in 2011 to use cell and molecular biology approaches to investigate rare genetic disorders with a focus on abnormalities of intracellular trafficking.

Our long-standing interest is in understanding the mechanism of function of a multi-protein tethering complex containing VPS33B and VIPAR. Defects in these two proteins cause a multi-system human disorder Arthrogryposis, Renal Dysfunction and Cholestasis Syndrome (ARC). For this work and other studies we employ cell and animal models of human disease including patient-derived induced pluripotent stem cells that can undergo differentiation into a variety of highly specialised cell types.