Research Synopsis
The Gissen Lab was set up in 2011 to use cell and molecular biology approaches to investigate rare genetic disorders with a focus on abnormalities of intracellular trafficking.
Our long-standing interest is in understanding the mechanism of function of a multi-protein tethering complex containing VPS33B and VIPAR. Defects in these two proteins cause a multi-system human disorder Arthrogryposis, Renal Dysfunction and Cholestasis Syndrome (ARC). For this work and other studies we employ cell and animal models of human disease including patient-derived induced pluripotent stem cells that can undergo differentiation into a variety of highly specialised cell types.
Selected Publications
About the lab
Funders
Medical Research Council
European Research Council
Batten Disease Family Association
GOSH Charity
Research Themes
Technology
People
Collaborators
Federico Forneris (University of Pavia, Italy)
Irwin Arias (National Institutes of Health, USA)
Steve Watson (University of Birmingham, UK)
Adrian Thrasher (UCL GOS Institute of Child Health, UK)
Simon Waddington (UCL Institute for Women’s Health, UK)
Paolo De Coppi (UCL GOS Institute of Child Health,UK)
Manju Kurian (UCL GOS Institute of Child Health, UK)
Michael Devine (UCL Institute of Neurology, UK)
Kevin Mills (UCL GOS Institute of Child Health, UK)
Philippa Mills (UCL GOS Institute of Child Health, UK)
Peter Clayton (UCL GOS Institute of Child Health, UK)