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LMCB - MRC Laboratory for Molecular Cell Biology

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Research Synopsis

Growing tissues are exposed to a variety of intrinsic and extrinsic mechanical forces and biochemical signals that sculpt the tissue to its final architecture. The extracellular matrix (ECM) is a complex dynamic meshwork of proteins that surrounds most tissues and provides a platform for mechanical and biomechanical cues. Dysregulation of ECM components can lead to developmental defects and pathological conditions in infants and adults. While biochemical signalling downstream of the ECM has been extensively studied, little is known about the mechanical role of the ECM in shaping tissues. As a mechanically stable scaffold, ECM can also help tissues to maintain their homeostatic morphology. Using Drosophila wing disc as a model system and taking an interdisciplinary approach, combining mechanical testing, imaging and computational modelling, I would like to understand the mechanical role of the ECM in shaping and maintaining tissue architecture.
 

Biography

2017 | PhD Biophysics, University College London, UK
2012 | MRes Modelling Biological Complexity, University College London, UK
2011 | BSc Physics, Sharif University of Technology, Tehran, Iran
 

Funders

Medical Research Council 

Research Themes

Cytoskeleton and cell cortex, Polarity and cell shape
 

Technology

Light microscopy, Super-resolution microscopy