My project investigates how oncogene-induced changes to nuclear architecture affect genome stability. Cancer cells fundamentally differ from normal cells in the shape and structure of their nuclei. Such differences are one of the histological criteria used for cancer diagnosis and staging. Surprisingly, if and how these changes to nuclear architecture affect genome stability and their role in cancer initiation and progression remains largely unknown. Establishing the mechanisms of how oncogenic activity affects genome integrity is therefore central to the understanding of cancer evolution and heterogeneity and is crucial for their subsequent diagnosis and treatment.