LMCB - Laboratory for Molecular Cell Biology

Christopher Minnis's picture

Postdoctoral research fellow, Mole Lab


LinkedIn | ORCID

Research synopsis

Researching a childhood neurodegenerative disorder called Batten disease. In particular, our lab focuses on the most common form Juvenile CLN3 disease. I work with a variety of models from simple eukaryotic (S. pombe), to primary patient cells and zebrafish models (D. rerio).
I utilise S. pombe (fission yeast) for synthetic genetic arrays and drug discovery high throughput screens. I have dissected consequence and function of mutations including the most common an intragenic ‘1kb deletion’. Identifying small molecules and genetic targets that ameliorate our phenotypic markers. I’ve a passion for translating academic research into innovative technology and biotech start-ups. Currently, I am continuing my researching on this foundation expanding our understanding of the pathogenic mechanism behind Batten disease and btn1/CLN3 function. 


2020 | PhD LIDo Interdisciplinary Neuroscience, Royal Veterinary College / UCL
2014 | MSc Veterinary and Human Epidemiology, Royal Veterinary College
2014 | MSc Dip Epidemiological Statistics, The London School of Hygiene and Tropical Medicine 
2012 | BA (Hons) Natural Science, Trinity College Dublin


2019-2020 | The Children’s Brain Diseases Foundation (USA)
2018-2019 | International Society of Neurochemistry
2015-2019 | LIDo Travel Grant Award 
2015-2019 | NCL Stiftung bursaries 
2015 | LIDo PhD RVC studentship
2008 | Trinity College Entrance Award 


European Research Council BATCure
BBSRC LIDo award
The Children’s Brain Diseases Foundation

Research themes

Cellular pathways
Juvenile CLN3 disease
Lysosomal storage diseases
Drug discovery


Light microscopy
High throughput screening
Schizosaccharomyces pombe
Mammalian cell cultures
Synthetic genetic array