New publication in Journal of Biological Chemistry for Saiardi Lab
In their recent publication in Journal of Biological Chemistry, the Saiardi Lab build on their discovery of a novel post-translational modification of lysine residues in budding yeast, known as polyphosphorylation.
New publication in Cell Reports for Acton Lab
Fibroblastic reticular cells control matrix production for lymph node conduit function. In a recent publication in Cell Reports, Martinez and colleagues show that matrix production is reduced and conduit flow is altered during lymph node expansion.
New publication in PNAS for Saiardi Lab
Inositol phosphates are a class of small molecules involved in signalling and metabolism. The wide breadth of functions they are associated with, including cell migration, DNA repair, telomere length maintenance, insulin sensitivity, phosphate homeostasis, cell cycle regulation, and necroptosis, testifies to the importance of these molecules in biology.
A collaborative paper in Developmental Cell for the Stefan Lab
Membrane contact sites (MCS) between the endoplasmic reticulum (ER) and the plasma membrane (PM) play fundamental roles in all eukaryotic cells.
New publication in ACS Chemical Biology for Saiardi Lab
Inositol and phosphate, can, in combination, produce a library of cell signaling molecules, simply referred as inositol phosphates. The fully phosphorylated inositol ring known as inositol hexakisphosphate (InsP6) controls various cellular functions directly or indirectly as precursors of inositol pyrophosphates such as InsP7 and InsP8.
New publication by Baum and Saric Labs in BMC Biology
ESCRT-III is a ubiquitous biological nanomachine that reshapes and cuts cell membranes in a wide range of cellular processes, from vesicle formation, HIV and Ebola release, to cell division.