LMCB - MRC Laboratory for Molecular Cell Biology


New collaborative publication for Saiardi Lab in Cell Reports

New collaborative publication in Cell Report for the Saiardi Lab, Javier Jiménez and Samuel Bru (Universitat Internacional de Catalunya). The work describes the biochemical identification and characterisation of the first mammalian enzyme responsible for inorganic polyphosphate (polyP) processing. Nudt3 is the mammalian polyP phosphatase. Interestingly, cations are able to modulate Nudt3 substrate specificity becoming active toward polyP in presence of zinc-mobilised after oxidative stress. Thus, polyP degradation is essential for cell survival upon oxidative stress.