LMCB - MRC Laboratory for Molecular Cell Biology


Collaborative publication in Cancer Discovery for de Bruin Lab

The de Bruin lab contributed to a new study from the Swanton lab, at the Francis Crick Institute, published in Cancer Discovery, investigating the role of APOBEC in cancer evolution. The work shows that APOBEC3 exacerbates DNA replication stress & chromosomal instability in early breast & lung cancer. These findings suggest that APOBEC3 is functionally implicated in the onset of chromosomal instability and somatic mutational heterogeneity in pre-invasive disease, providing fuel for selection early in cancer evolution.