LMCB - MRC Laboratory for Molecular Cell Biology


New review in Biochimica et Biophysica Acta by Nishimura and Stefan

A new review in BBA Molecular and Cellular Biology of Lipids by Taki Nishimura and Chris Stefan discusses specialized ER membrane domains for lipid metabolism and transport, highlighting past and recent findings, and unresolved questions in the field.

Abstract from the review:

The endoplasmic reticulum (ER) is a highly organized organelle that performs vital functions including de novo membrane lipid synthesis and transport. Accordingly, numerous lipid biosynthesis enzymes are localized in the ER membrane. However, it is now evident that lipid metabolism is sub-compartmentalized within the ER and that lipid biosynthetic enzymes engage with lipid transfer proteins (LTPs) to rapidly shuttle newly synthesized lipids from the ER to other organelles. As such, intimate relationships between lipid metabolism and lipid transfer pathways exist within the ER network. Notably, certain LTPs enhance the activities of lipid metabolizing enzymes; likewise, lipid metabolism can ensure the specificity of LTP transfer/exchange reactions. Yet, our understanding of these mutual relationships is still emerging. Here, we highlight past and recent key findings on specialized ER membrane domains involved in efficient lipid metabolism and transport and consider unresolved issues in the field.