LMCB - Laboratory for Molecular Cell Biology



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Day 1 | Monday June 3
15:00 Meeting registration opens
17:30-18:00 Welcome
17:45-18:45 Keynote Lecture | Rong Li | The diverse cell cycle
18:45-19.15 Snacks and nibbles
Session 1 | Diversity in cell cycle control
19.15-19:20 Introduction to session | Chair Zhaohua Tang
19.20-19:45 Ines Drinnenberg | Loss is more: Evolution of CenH3-independent chromosome segregation in holocentric insects
19:45-20:10 Geert Kops | Weird divisions: Evolutionary dynamics of eukaryotic kinetochores
20:10-20:25 Maria Rosa Domingo Sananes | Paradoxical diversity of cell cycle control across eukaryotes
20:25-20:40 Gabriel Tarrason Risa | Proteasomal degradation of archaeal ESCRT-III is a key event in the mitotic exit of Sulfolobus acidocaldarius
21:00 Welcome reception | Aperitif with finger food at historic Caffe' degli Specchi
Day 2 | Tuesday June 4
Session 2 | Genome duplication and stability I 
9:00-9:05 Introduction to session | Chair Bart Westendorp
9:05-9:30 Jenny Wu | Modulating the replication program: inputs from CDK regulation
9:30-9:55 John Diffley | Chromosome Replication: From Mechanism to Misregulation in Cancer
9:55-10:10 Carolin Müller | Capturing the dynamics of genome replication on individual ultra-long nanopore sequence reads
10:10-10:25 Kurt Schmoller | Template-limited transcription coordinates histone homeostasis with DNA content
10:25-11:00 Coffee break
Genome duplication and stability II 
11:00-11:25 Maria Pia Longhese | Regulation of the MRX complex at DNA double-strand breaks
11:25-11:50 Tanya Paull | Cell Cycle Regulation of Protein Homeostasis
11:50-12:05 Karl-Uwe Reusswig | A cell cycle-specific response to DNA over-replication
12:10-13:00 Lunch at Venue
13:00-15:00 Posters
Session 3 | Chromosome segregation and cytokinesis I
15:00-15:05 Introduction to session | Chair Ethel Querair
15:05-15:30 Frank Uhlmann | Control over Temporal Order during Cell Cycle Progression
15:30-15:55 Adrian Saurin | Signal integration at the kinetochore
15:55-16:10 Giorgia Benzi | A common molecular mechanism underlies the function of Mps1 in chromosome segregation and Spindle Assembly Checkpoint
16:10-16:25 Manuel Mendoza | Budding yeast complete DNA replication after chromosome segregation begins
16:30-17:10 Coffee break
Chromosome segregation and cytokinesis II
17:10-17:35 Silke Hauf | Features of spindle assembly checkpoint gene expression
17:35-18:00 Iain Cheeseman | Modulating and Rewiring Kinetochore Function
18:00-18:15 Chloe Snider | The Cdc15 F-BAR simultaneously binds membrane and scaffolds protein partners to promote proper organization of the cytokinetic ring
18:15-18:30 Gerard Pieper | ESCRT-III/Vps4 controls heterochromatin-nuclear envelope attachments
18:30 Organised tours of Trieste
Day 3 | Wednesday June 5
Session 4 | Cell cycle decision-making I
9:00-9:05 Introduction to session | Chair Silvia Santos
9:05-9:30 Jan Skotheim | Cell growth dilutes the cell cycle inhibitor Rb to trigger cell division in human cells
9:30-9:45 Helfrid Hochegger  | Towards a quantitative model of mitotic cell cycle control in human cells 
9:45-10:00 Jennifer Ewald | Multiple layers of phospho-regulation coordinate metabolism and the cell cycle
10:00-10:35 Coffee break
Cell cycle decision-making II
10:35-11:00 Damien Coudreuse | Cell cycle regulation: simpler is better?
11:00-11:25 Bela Novak | Decision-making during multiple-fission cycle
11:25-11:40 Michael Boemo | Modelling Made Easy: A Programming Language for Cell Cycle Processes
11:40-13:30 Lunch time
13:30-15:00 Posters
Session 5 | Cell cycle decision-making III
15:00-15:05 Introduction to session | Chair Agathe Chaigne
15:05-15:30 EMBO Young Investigator Lecture | Bungo Akiyoshi | Understanding the mechanism of chromosome segregation: lessons from kinetoplastid parasites
15:30-15:55 Kathy Gould | A tail of kinase regulation:  how C-termini modulate CK1 substrate phosphorylation
15:55-16:10 Arne Lindqvist | Why is G2 phase not shorter?
16:10-16:25 Lendert Gelens | Self-organization of mitotic waves depends on the spatial geometry of the system
16:20-17:10 Coffee break
Cell cycle decision-making IV 
17:10-17:35 Folkert van Werven | Cell fate control by an alternative transcriptome
17:35-18:00 Stefano Di Talia | Waves and flows: physical principles of organization of early embryogenesis and regeneration
18:00-18:15 Patrick O'Farrell | The role of the cell cycle in the initial events in embryonic differentiation of the genome
18:15-18:30 Masamitsu Sato | Virtual time-lapse single cell transcriptomes revealed a ‘wake-up’ strategy for dormant cells at cell cycle initiation
19:00 Pizza party
Day 4 | Thursday June 6
Session 6 | Genome integrity and disease I
9:00-9:05 Introduction to session | Chair Katja Wassmann
9:05-9:30 Orna Cohen-Fix | How do parental genomes mix after fertilization?
9:30-9:55 Julie Cooper | Why centromeres fall apart in meiosis, and how telomeres promote their reassembly
9:55-10:10 EMBO Young Investigator Lecture | Ross Chapman | PLK4 inhibition is synthetic lethal with high TRIM37 expression in 17q23-amplified breast cancer cells
10:10-10:25 Izabela Sumara | Spatial control of nucleoporin assembly by Fragile X syndrome proteins during early G1
10:25-11:00 Coffee break
Genome integrity and disease II
11:00-11:25 Sarah McClelland | Analysing chromosome-specific behaviour to reveal novel mechanisms governing genome stability
11:25-11:50 Giulia Rancati | Environmental stresses induce karyotypic instability in colorectal cancer cells
11:50-12:05 Jet Segeren | Heterogenous DNA damage response allows escape from replication stress-inducing drugs
12:05-12:30 Closing remarks