Module Database

Information for module BIOCG006

This module is available for 2017/18

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Module code:BIOCG006 (Add to my personalised list)
Title:Mechanisms of Molecular Machines I
Credit value:15
Division:Division of Biosciences
Module organiser (provisional): Dr Finn Werner
Organiser's location:Research Department of Structural and Molecular Bi
Available for students in Year(s):3, 4
Module prerequisites:BIOC1007, 2001 and 2004 
Module outline:New! This course has undergone a radical restructuring and now encompasses some of the most recent scientific discoveries and technical innovations. Twelve SMB lecturers teach their own research highlights on this course and in addition we have recruited four leading experts (from Birkbeck College, the National Institute for Medical Research and UCL Chemistry) to give guest seminars. Biochemistry 3003 takes the student on a journey that follows the flow of information in the cell, starting with nucleic acid synthesis and its regulation (replication, transcription, DNA repair and recombination, regulation by small noncoding RNAs), continuing with protein synthesis (translation) and ending with protein folding (chaperoning). The course aims to provide an in-depth understanding of protein structure and function. A number of structural, biochemical and biophysical methods are embedded in the course allowing the students to familiarise themselves with technologies including protein crystallography, nuclear magnetic resonance (NMR), electron microscopy (EM), F�rster resonance energy transfer (FRET), isothermal calorimetry (ITC), UV photo cross linking and cleavage.  
Module aims:The aims of the course are to develop the basic theory and practical understanding derived from the previous year into a state-of-the-art knowledge of key issues in protein and nucleic acid structure and function. The course provides lectures divided into two themes: (i) Nucleic acids synthesis and its regulation and (ii) protein translation and folding.  
Module objectives:To provide the students with an understanding of biomolecular mechanisms and to familiarise themselves with a range of principles and methods in structural and molecular biology, biochemstry and biophysics.  how high resolution structures aid in an understanding of protein function of selected enzymes  how biophysical and biochemical proximity probing inform about multiprotein complex architecture  the principles of protein-nucleic acid interactions  the determinants of protein folding and how it can be aided by chaperonins  
Key skills provided by module: 
Module timetable: 
Module assessment:Invigilated on-line essay (3,000 words) 30.00%
Coursework (3,000 words) 30.00%
Invigilated on-line test one 20.00%
Invigilated on-line test two 20.00% 
Taking this module as an option?: 
Link to virtual learning environment (registered students only) 
Last updated:2016-09-28 09:33:02 by ucbchbe