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Information for module BIOC2004

This module is available for 2016/17 and 2017/18 (provisional)

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Module code:BIOC2004 (Add to my personalised list)
Title:Biomolecular Structure and Function
Credit value:1
Division:Division of Biosciences
Module organiser (provisional):Dr S Djordjevic
Organiser's location:Dept of Structural & Molecular Biology
Available for students in Year(s):2
Module prerequisites:First year Biochemistry 1001 or Biochemistry 1007 
Module outline:This module provides the students with fundamental principles of theory and practical aspects of protein science that investigates the intricate relationship between biomolecular structure and function and enzymology. The material is presented at a level suitable for the students from a range of first year degree programmes, and to a depth appropriate both for the students who will not continue to study in the subject area and those who will progress to advanced (third year) protein structure/function courses. The course consists of lectures, small group tutorials, laboratory practicals and workshops. 
Module aims:The main aim of this course is to provide an understanding of the biochemical theory and practical techniques relevant to protein and enzyme structure, function and analysis. 
Module objectives:The objectives of the course are to provide lectures, tutorials, workshops and practical teaching on: Primary, secondary, tertiary and quaternary protein structure; Protein folding and unfolding; Heterologous protein expression and purification methods; Structure determination and functional analysis of proteins; Enzyme kinetics and assay methods; Enzyme mechanisms and co-enzyme function; Modified proteins including lipoproteins and antibodies. This will enable students: 1) To understand the basis of the mechanisms, thermodynamics and kinetics of protein folding and the nature of the forces which maintain the native state. 2) To understand the role of higher orders of structure, including secondary, super-secondary and domain structures. 3) To appreciate the physical and chemical methods used in the determination of three-dimensional protein structure. 4) To become familiar with the principles, practice and problems associated with heterologous protein expression and separation. To become aware of the high-troughput methods used in protein production. 5) To understand the principles of simple one and two-substrate enzyme reaction kinetics and to be able to determine experimentally the basic kinetic constants for an enzyme reaction. To be familiar with the importance of co-enzymes in enzyme reaction mechanisms. 6) To understand the structures and functional roles of number of proteins, in particular haemoglobin, DNA polymerase, proteins in bacterial pilus biogenesis, antibodies, lipoproteins and membrane proteins.  
Key skills provided by module: 
Module timetable: 
Module assessment:In-course test 15.00%
Unseen two hour written examination 70.00%
Practical reports 15.00% 
Taking this module as an option?: 
Link to virtual learning environment (registered students only) 
Last updated:2014-02-27 15:24:04 by ucbcsdj