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Information for module GENEG008

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Module code:GENEG008(Add to my personalised list)
Title:Clinical Applications in Pharmacogenetic Tests
Credit value:15
Division:Division of Biosciences
Module organiser:Professor Steve Humphries
Organiser's location:Rayne Institute
Available for students in Year(s):
Module prerequisites:Available to masters students only  
Module outline:The module consists of two parts. The first is a series of seven, hour long lectures which cover the basic principles of pharmacogenetics. In the remaining 8-9 teaching slots, students will each be allocated a disease or disease area (allocation at the commencement of the course) and will be asked to prepare a presentation giving background about the disease, a review of the various medications being used to treat the disease, a review of the current evidence for genetic differences determining response to medication and risk of adverse drug responses and a proposal for future research activities.  
Module aims:The module aims to teach students about the current state of pharmacogenetic research, with an emphasis on translating research findings into clinical benefit. 
Module objectives:The student will gain experience in the following areas : Overview of nomenclature used for genetic variants influencing drug metabolism; Evaluation of predictive genetic tests using sensitivity, specificity, predictive accuracy; Critical appraisal of study designs in pharmacogenetics; Evaluation of pharmacogenetic studies within clinical trials, tests of treatment effect in marker positive individuals and influence on marker status in treated individuals; Methods for summarizing information from multiple pharmacogenetic studies (meta-analysis); Critical review of published pharmacogenetics data, public presentation of summary data and insight into research possibilities. 
Key skills provided by module: 
Module timetable: 
Module assessment:Two-hour unseen written exam 60.00%.
Topic review and Journal Club presentation 40.00%. 
Taking this module as an option?: 
Link to virtual learning environment(registered students only) 
Last updated:2012-07-17 16:44:15 by