Information for module GENEG003
This module is available for: The current academic year
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|Module code:||GENEG003(Add to my personalised list)|
|Title:||Genetics of Neurological Disease|
|Division:||Division of Biosciences|
|Module organiser:||Professor Nick Wood/Dr Alan Pittman|
|Organiser's location:||Institute of Neurology|
|Available for students in Year(s):|
|Module prerequisites:||Available to MSc students Only|
|Module outline:||Disorders of the nervous system are common and disabling. Although individually rare, cumulatively, Mendelian disorders affecting the nervous system function constitute a significant disease burden. Moreover huge insights have been gained by the study of the molecular pathogenesis of these disorders. In some instances whole new fields of genetic and molecular pathology have been elucidated (e.g. triplet repeat disorders). Genetics has also contributed to our understanding of a range of neurodegenerative conditions including common disorders such as Alzheimer's disease and Parkinson's disease. In fact there is no branch of neurology that has not had a direct and often dramatic impact of discovery of genetic defects. This situation is likely to continue with the technological advances allowing whole genome mapping for common traits. This module will give the students a background in the principal Mendelian diseases of the nervous system. The emphasis will be on providing them with a template to which they can add the emerging and rapidly changing genetic and molecular discoveries. Finally it will introduce the role of complex trait genetics in neurological disease which will tie in with other modules within the MSc.|
|Module aims:||To provide the core principles of the genetics of major neurogenetic disorders. To provide information of both the molecular pathogenesis and the clinical phenotypes involved. To allow the students to have a broad but firm basis in the emerging genetic technologies as they apply to neurological disease.|
|Module objectives:||Knowledge of the principal modes of inheritance. An understanding of the genetic principles involved with mapping and identification of disease genes. An understanding of the challenges and limitations of genotype-phenotype correlation studies as applied to neurological disease. A knowledge of the principal neurogenetic conditions and what is currently known of their molecular pathogenesis. An introduction to complex trait analysis as applied to neurological disease.|
|Key skills provided by module:|
|Module assessment:||Two journal club presentations (20 minutes each plus 10 minutes questions 15.00%.|
Unseen three-hour written examination 70.00%.
Grant writing excercise 15.00%.
|Taking this module as an option?:|
|Link to virtual learning environment(registered students only)||http://moodle.ucl.ac.uk/course/view.php?id=5003|
|Last updated:||2012-07-19 14:04:25 by|