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Information for module Cell2007

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Module code:CELL2007(Add to my personalised list)
Title:The Principles of Cellular Control
Credit value:.5
Division:Division of Biosciences
Module organiser:Prof Geraint Thomas
Organiser's location:Cell and Developmental Biology
Available for students in Year(s):2,
Module prerequisites:Open to negotiation but BIOC1001, CELL1001 and either BIOC2001 or BIOL2004 are usual.  
Module outline:This course will provide a strong introduction to the principles of cellular regulation and range across molecular and cellular scales. Using key examples students will learn how molecular mechanisms orchestrate cellular processes. In a wider context cell signaling will serve as a vehicle for students to discover how to fuse an understanding of molecular concepts with macroscopic biology. Lectures will concentrate on: the molecular properties of different classes of receptors; the structure-function relationships of kinases, small and heterotrimeric G-proteins; second messenger molecules and the enzymes that generate them, structure-function in the recognition and binding of phosphoproteins and second messengers; signalling through polyphosphoinositides; integration of molecular-scale information into an understanding of major signaling pathways; adrenalin, insulin and EGF and the Wnt/catenin signaling pathways in example processes like energy metabolism, cancer biology, circadian rhythmicity and tissue differentiation. The course contains a compulsory one-week laboratory component (during the February reading week) that will provide a hands-on introduction to; 1/ Techniques of mammalian cell culture, propagation and transfection with foreign DNA; 2/ Fluorescent and visible light microscopy; 3/ The deduction of the organisation of signaling pathways through epigenetic study of C. elegans with mutations in genes coding signaling proteins; 4/ The application of basic bioinformatics to studies of signalling molecules.  
Module aims:To provide an introduction to the principles of cellular regulation. Using examples, students will understand how molecular-scale mechanisms orchestrate cellular process and events. The component will also enhance the learning provided by the immediately preceding CELL2006 Cell Biology course and prepare students for more specialized 3rd year study. However you will not be permitted to study both CELL2006 and CELL2007 as two separate courses - to combine them you must study CELL2008 Integrative Cell Biology. 
Module objectives:Cell signaling will serve as a vehicle for students to discover how to fuse an understanding of molecular scale concepts and mechanisms with cell biological, metabolic and developmental consequences. In this way, comprehension of both the scope and the limitations of molecular genetic and biochemical interventions in the investigation of the processes of life will be arrived at.  
Key skills provided by module:Cell and tissue culture techniques. Data manipulation and presentation. Computer techniques applicable to molecular and cellular biology. Creation of html documents and publication of web pages.  
Module timetable: 
Module assessment:1 project and 1 laboratory report 25.00%.
Unseen two-hour written examination 75.00%. 
Notes:The "practical week" component starts on the Monday of the February "reading week" (usually the 6th week of term). To be complete for CELL2007 a candidate must submit by the required deadlines the coursework project and at least 1 from the 2 sections that comprise the laboratory report. 
Taking this module as an option?: 
Link to virtual learning environment(registered students only) 
Last updated:2014-08-27 20:55:31 by