Module Database

Information for module BIOCG016

This module is available for: The current academic year

If you're a member of UCL you can add this module to your personalised course list

This information is for guidance only. If you are a UCL undergraduate interested in studying one of these courses, you must seek permission from both the providing department and your 'home' department. Appearance in this database is not a guarantee that a course is running in any particular academic year.


Module code:BIOCG016(Add to my personalised list)
Title:Genes to Disease
Credit value:15
Division:Division of Biosciences
Module organiser:Professor Surjit Kaila Srai
Organiser's location:Darwin Building
Organiser's email:k.srai@ucl.ac.uk
Available for students in Year(s):3,4,
Module prerequisites:Strong background knowledge of biochemistry, cell biology and basic genetics. Students wishing to take this module are strongly encouraged to have 2.1 or higher average in Year 2.This module cannot accommodate more than 60 students. Should the module size exceed 60, the criteria outlined above will become mandatory for confirmation of enrolment on BIOC3016.  
Module outline: 
Module aims:To introduce students to: advanced aspects of molecular genetics; the relationship between genes and neurodegenerative diseases at the molecular level and our current understanding of the disease mechanisms of important human neurodegenerative diseases.  
Module objectives:Neurodegenerative diseases are a very important cause of morbidity and mortality and with an ageing population they are becoming more prevalent. This course aims to equip the students with an in depth understanding of the molecular basis of a variety of important neurodegenerative diseases and how this has contributed to our current understanding of their disease mechanisms. It begins with coverage of basic and more advanced aspects of molecular genetics; an understanding of the various model systems used to investigate these diseases; a description of common pathways involved from a biochemical and cell biology perspective including the importance of protein aggregation, free radical mechanisms, iron regulation and mitochondrial function and the use of stem cells to study and treat the diseases. Finally more detailed clinical, pathological, genetic and mechanistic issues are covered for a number of diseases including: Parkinson’s disease, Alzheimer’s disease, prion diseases, hereditary spastic paraplegia, motor neuron disease, mitochondrial diseases and Huntington’s disease.  
Key skills provided by module:Students will learn basic and advanced molecular genetics, an understanding of the genetic basis of a variety of neurodegenerative diseases and how this has improved knowledge of pathogenetic mechanisms. You will be provided with the latest knowledge of how important neurodegenerative diseases are caused and the mechanisms that underlie the pathology and clinical symptoms. You will be exposed to a broad spectrum of academic and transferable skills. An important opportunity to read, discuss and critically evaluate a variety of recent research papers covering topics related to the lecture topics. The Journal Club format will enable presentation and discussion skills to be developed in a group atmosphere to evaluate and discuss new research data and how it improves our understanding of the causes, mechanisms and potential therapeutic intervention in these important diseases. Opportunities to explore the latest research findings will be further explored in tutorials and the evaluation of a research paper for an ICA.  
Module timetable:https://cmis.adcom.ucl.ac.uk:4443/timetabling/moduleTimet.do?firstReq=Y&moduleId=BIOCG016 
Module assessment:ICA reference evaluation (1,800 words) 10.00%.
Unseen two-hour written examination 70.00%.
ICA Journal Club presentation (8 minutes) 10.00%.
ICA research essay (2,000 words) 10.00%. 
Notes:Assessments: BSc/IBSc ICA - Reference review 1800 words (15%) - Group Journal Club presentation/summary (15%) End of year exam - 2 essays from 6 questions over 2 hours (70%) MSci/MRES/MSc ICA - Reference review 1800 words (10%) - Group Journal Club presentation/summary (10%) - research question essay 2000 words (10%) End of year exam - 2 essays from 6 questions over 2 hours (70%)  
Taking this module as an option?: 
Link to virtual learning environment(registered students only) 
Last updated:2016-08-02 11:45:33 by