Menu

Design of Experiments for Bioprocess Optimisation (MBI® Training, Bioprocess Industries)

  • 18 hours (approx)
  • 3 days

Overview

This three-day course explores how to use experimental design techniques to rapidly understand and optimise bioprocess performance.

You'll learn how experimental design and small scale experimental models can underpin Quality by Design (QbD) approaches.

You'll also get hands-on training on Design of Experiments (DoE) software.

This course is for laboratory scientists and engineers and managers.

This course is part of the Modular Training for the Bioprocess Industries programme (MBI®), run by the Department of Biochemical Engineering at UCL.

Course content and structure

Teaching is in small classes, with an emphasis on interactive problem solving and case studies.

Each day will cover the following topics:

Day 1

  • The principles and benefits of DoE approaches, compared to one-factor-at-a-time (OFAT) investigations
  • Experimental design techniques and interactive demonstration of DoE software packages (Design Expert 8 and ProSim)
  • Case studies: analytical method validation (conventional vs DoE approach)
  • Industrial analytical method validation using DoE

Day 2

  • Screening and optimisation of microbial fermentations
  • Case study: fermentation process screening
  • Case study: fermentation process optimisation and scaleup
  • Protein refolding, stabilisation and formulation: structural and environmental parameters that impact on maintenance and stabilisation of protein structure and activity

Day 3

  • Case study: primary product recovery by microfiltration
  • The application of factorial design in high throughput scale-down bioprocess development: examples in fermentation and cell culture
  • Experimental planning and DoE for chromatography
  • Discussion forum

A social networking event will be held for delegates and speakers.

Who the course is for

The course is for anyone involved in bioprocess development and optimisation including:

  • bioprocess applications specialists
  • hands-on bioprocess scientists and engineers
  • research managers and consultants

Learning outcomes

After completing this course you should be able to:

  • generate appropriate experimental designs within fixed research budgets and timescales
  • ensure analytical methods can be validated and provide reliable data for process evaluation
  • rapidly screen and optimise different fermentation media and operating conditions
  • obtain the highest yield of active product throughout your downstream process sequence
  • understand the relationship between DoE and QbD

Costs and group bookings

Please contact mbi-training@ucl.ac.uk for information about costs and group bookings.

Course fees include materials, lunches and refreshments. Accommodation isn't included, but details of special rates at nearby hotels will be sent with your registration pack.

Modular Training for the Bioprocess Industries (MBI®)

The award-winning MBI® programme is a series of UCL-accredited short courses for people working in the bioprocessing industry. It's designed and delivered in collaboration with over 70 industrial experts.

The programme provides flexible professional development training. You can choose to take standalone courses or combine them for a Certificate, Diploma or Master’s qualification. It complements in-house training by providing broader perspectives for more informed decision-making.

Courses have so far been delivered to over 900 individuals from more than 300 companies, 30% of which are non-UK, demonstrating its strong international impact.

MBI® plays a central role in the department’s knowledge-transfer activities. This ensures that cutting-edge research is undertaken to capture the value of integrating engineering with complex and fast-moving biology, which helps keep the global industry ahead in manufacturing.

Benefits of MBI®

By attending an MBI® course, you'll:

  • benefit from knowledge transfer and upskilling in core bioprocessing fundamentals and trends in industry
  • gain a deeper understanding of process options and engineering constraints
  • acquire the tools to optimise process performance and economics
  • learn about the latest technical and regulatory developments
  • have access to cutting edge research methodologies
  • network with sector leaders and subject matter experts
  • increase your flexibility, motivation, creativity and professional status

Further information

There is more information about the MBI® on the Department of Biochemical Engineering's website. If you have questions about fees or how to combine courses for a specific qualification, please email mbi-training@ucl.ac.uk

Course team

Dr Andrea Rayat - Module Leader

Andrea is Lecturer in Bioseparations (Downstream Processing) in the Department of Biochemical Engineering at UCL.


Course information last modified: 07 Mar 2019, 15:45

Share