Papers from Professor Sandip Patel (UCL CDB) and colleagues, published in Cell Calcium and Trends in Biochemical Sciences discuss recent work to identifying the elusive NAADP-BPs as Jupiter microtubule associated homolog 2 (JPT2) and ‘like-Sm’ protein 12 (LSM12). These discoveries enable new insight into this signaling pathway and the role of NAADP in cellular physiology and disease.