The work, which was led by Duchen lab PhD student Chih-Yao Chung, highlights the role of dysfunctional cell signaling pathways associated with a mtDNA mutation that causes the disease ‘MELAS’ for which there is no treatment. We have shown that bioenergetic function can be rescued by drugs which inhibit those signaling pathways, suggesting possible novel therapeutic approaches.
Chih-Yao Chung (centre) with Will Kotiadis who started the work (left) and Nicoletta Plotegher (right)
Read the Open Access article at: https://www.nature.com/articles/s41467-021-26746-2