Our research investigates how the nervous system learns to shape adaptive movement from early life experience. We study how spinal and cortical circuits develop the ability to generate precise, context-appropriate actions, and how adverse early environments may disrupt these processes, contributing to chronic pain and movement disorders.
Collaborations
Learn more about our collaborations with scientists at UCL, other universities, and scientific bodies.
Our principal funders
Selected publications
Andreoli L, Constantinescu AM, Gorai A, Black CJ, Koch SC (2025) Discrete and sequential critical periods organise the development of task‑specific somatosensory circuits in mice. BioRxiv doi:10.1101/2025.09.18.676788
Black C, Browne LE, Brownstone RB, Koch SC (2025) Ethologically relevant behavioural assay for investigating reach and grasp kinematics during whole-body motor control in mice. BioRxiv doi:10.1101/2025.04.04.647225
Meng, J., Ma, S., …Koch S, … Zhou, H. (2025). Antisense oligonucleotides reverse SPTLC1-related hereditary sensory neuropathy in a mouse model. Brain, awaf403. doi:10.1093/brain/awaf403
Xu, Y., Koch, SC., Chamessian, A., He, Q., Sundukova, M., Heppenstall, P., … Beggs,
S. (2024). Microglial refinement of A-Fiber projections in the postnatal spinal
cord dorsal horn Is required for normal maturation of dynamic touch. Journal of Neuroscience, 44(2). doi:10.1523/JNEUROSCI.1354-23.2023
Russ DE, Cross RBP, Li L, Koch SC, Matson KJE, Yadav A, … Levine AJ (2022). A harmonized atlas of mouse spinal cord cell types and their spatial organization. Nature Communications, 13(1), doi:10.1038/s41467-022-33998-z
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Koch Lab
Click to email. s.koch@ucl.ac.uk