Our group is interested in studying human evolutionary history, focusing on how genetic and epigenetic variation facilitates the adaptation of humans to environmental pressures, and how this affects human health today. This currently includes collaborations with institutes in the Gambia and Japan, analysing both large-scale biobank-level datasets and DNA from ancient human remains (aDNA).
Hellenthal Lab
Hellenthal Lab
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Selected Publications
Hu, S., Ferreira, L.A.F., Shi, S. et al. Fine-scale population structure and widespread conservation of genetic effect sizes between human groups across traits. Nat Genet 57, 379–389 (2025).
Nancy Bird et al. Dense sampling of ethnic groups within African countries reveals fine-scale genetic structure and extensive historical admixture. Sci. Adv.9,eabq2616(2023). DOI:10.1126/sciadv.abq2616
P. Wangkumhang, M. Greenfield, G. Hellenthal. An efficient method to identify, date, and describe admixture events using haplotype information. Genome Res. 32, 1553–1564 (2022).
Maria Derakhshan, Noah J Kessler, Miho Ishida, Charalambos Demetriou, Nicolas Brucato, Gudrun E Moore, Caroline H D Fall, Giriraj R Chandak, Francois-Xavier Ricaut, Andrew M Prentice, Garrett Hellenthal, Matt J Silver. Tissue - and ethnicity-independent hypervariable DNA methylation states show evidence of establishment in the early human embryo. Nucleic Acids Research, Volume 50, Issue 12, 8 July 2022, Pages 6735–6752.
Javier Mendoza-Revilla, J. Camilo Chacón-Duque, Macarena Fuentes-Guajardo, Louise Ormond, Ke Wang, Malena Hurtado, Valeria Villegas, Vanessa Granja, Victor Acuña-Alonzo, Claudia Jaramillo, William Arias, Rodrigo Barquera, Jorge Gómez-Valdés, Hugo Villamil-Ramírez, Caio C. Silva de Cerqueira, Keyla M. Badillo Rivera, Maria A. Nieves-Colón, Christopher R. Gignoux, Genevieve L. Wojcik, Andrés Moreno-Estrada, Tábita Hünemeier, Virginia Ramallo, Lavinia Schuler-Faccini, Rolando Gonzalez-José, Maria-Cátira Bortolini, Samuel Canizales-Quinteros, Carla Gallo, Giovanni Poletti, Gabriel Bedoya, Francisco Rothhammer, David Balding, Matteo Fumagalli, Kaustubh Adhikari, Andrés Ruiz-Linares, Garrett Hellenthal. Disentangling Signatures of Selection Before and After European Colonization in Latin Americans. Molecular Biology and Evolution, Volume 39, Issue 4, April 2022, msac076.
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Hellenthal Lab
Click to email. g.hellenthal@ucl.ac.uk