CDB Seminar - Dr Raman Das, University of Manchester

Talk abstract: Neuron polarisation is of fundamental importance, both during embryonic development and following injury in adults. During vertebrate central nervous system development, polarisation of newborn neurons leads to axon extension in the correct orientation, ultimately leading to the formation of functional neural circuitry. Similarly, peripheral neuron injury in adults is followed by rapid re-polarisation and axon extension to re-establish functional neural circuitry. However, the cell-intrinsic mechanisms through which neuron polarisation is achieved in both contexts remain poorly understood. To study these mechanisms, we deploy innovative methods to image and manipulate cellular behaviour in real time in high spatial and temporal resolution, in combination with cutting-edge super-resolution fixed imaging techniques. Here, I will discuss our ongoing work that identifies how molecular remodelling of the primary cilium allows differentiating neurons to switch their interpretation of Shh signalling and achieve normal axon extension. Furthermore, I will also discuss our ongoing work on the mechanisms through which injured adult peripheral neurons undergo large-scale microtubule remodelling in the absence of the centrosome to achieve robust axon regeneration.

Zoom: https://ucl.zoom.us/j/94065194716

Host: Dr Marc Amoyel