NPP & CDB Special Seminar - GL Brown Physiological Society Award, Prof Sandip Patel, UCL
Title: Ca2+ signaling through acidic organelles. From Ringer to the cell’s inner.
NPP & CDB Special Seminar - GL Brown Physiological Society Award, Prof Sandip Patel, UCL
28 Apr 2023, 15:00 – 16:00
Academic Host: David Attwell
Abstract: Changes in intracellular Ca2+ underpin our physiology. These changes are usually ascribed to entry of Ca2+ from the outside of the cell or release from the endoplasmic reticulum. But it is now clear that the so called ‘acidic Ca2+ stores’ are also part of the Ca2+ network. In this lecture, I discuss how lysosomes, once viewed solely as the cell’s recycling centre, are in fact dynamic Ca2+ signalling organelles in intimate contact with endoplasmic reticulum Ca2+ stores. I focus on a family of endo-lysosomal ion channels - the two-pore channels – that are activated by the second messenger NAADP, and describe some of their recently discovered properties which challenge the text book view of how ion channels work.
Seminar Location: Medical Sciences, 131 A V Hill LT, Medical Sciences and Anatomy
Drink Reception Location: LG40/41 Gertrude Falk Room - Biosciences PGR Student Hub rooms at 16:00 onwards
Hybrid
This seminar offering will be Hybrid style. This seminar offering will be Hybrid style. Join us in person (preferably) or online.
https://ucl.zoom.us/j/97610922265
Sandip Patel FRSB MAE is Professor at UCL.
He trained as a Medical Biochemist (Birmingham) and obtained his PhD in Pharmacology (Cambridge) with Colin Taylor followed by postdoctoral work with Andrew Thomas (Philadelphia/Newark) and Antony Galione (Oxford) as a Wellcome Trust International Travel Prize fellow. He started his own lab in Oxford which he moved to London in 2001, where is currently the Deputy Head of the Department of Cell and Developmental Biology.
Sandip’s work has helped develop the concept that acidic organelles such as lysosomes serve as patho-physiologically relevant stores of Ca2+.
He is and a member of several Editorial boards (including Cell Calcium) and Funding agency panels (including the Medical Research Council).
Further information
Ticketing
Open
Cost
Free
Open to
All
Availability
Yes
Organiser
Charlette Bent-Gayle
Neuroscience, Physiology and Pharmacology, UCL