NPP Seminar: Prof Riccardo Olcese, University of California Los Angeles

Abstract: Initiation of skeletal muscle contraction is triggered by rapid activation of RyR1 channels in response to sarcolemmal depolarization.  RyR1 is an intracellular channel and has no voltage-sensing structures, but it is coupled with the voltage-sensing apparatus of CaV1.1 channels to inherit voltage sensitivity.  Using an opto-electrophysiological approach, the Olcese laboratory at the University of California Los Angeles studies the excitation-driven molecular events controlling both CaV1.1 pore opening and RyR1 activation.  Each of the four CaV1.1 voltage-sensing domains exhibits unique biophysical properties in terms of kinetics and voltage dependence, providing a rationale for how CaV1.1, a slowly-activating channel, can trigger the rapid activation of RyR1.

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Meeting ID: 929 8555 3708
Passcode: 119860

Hosts: Ivan Kadurin and Annette Dolphin 

The Neuroscience, Physiology and Pharmacology (NPP) Seminar Series in partnership with The Physiological Society.