The de Bruin Lab studies how the cell cycle is regulated in healthy cells and how its disruption drives cancer. By revealing these mechanisms, we aim to uncover vulnerabilities that enable selective targeting of cancer cells while sparing normal tissue. Our work spans fundamental to translational research, identifying oncogene-induced stresses, assessing drug efficacy, and developing new strategies to target cell cycle control for improved cancer therapies.
de Bruin Lab
Research Projects
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Collaborations
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Selected publications
S. Peripolli, T. Singh, C. Perrod, H. Patel, L. Meneguello, S. Rahman, K. Kiso1, P. Thorpe, V. Calvanese, C. Bertoli and R. A.M. de Bruin. Oncogenic c-Myc induces replication stress by increasing chromatin occupancy of cohesins at CTCF sites. Nature Communications, January 2024.
G.A. Wilson, K. Vuina, G. Sava, C. Huard, L. Meneguello, J. Coulombe-Huntington, T. Bertomeu, R.J. Maizels, J. Lauring, J. Kriston-Vizi, M. Tyers, S. Ali, C. Bertoli1, and R.A.M. de Bruin. Active growth signalling promotes senescence and cancer cell sensitivity to CDK7 inhibition. Molecular Cell, November 2023.
S. Manohar, M. E. Estrada, F. Uliana, K. Vuina, P. Moyano Alvarez, R.A.M. de Bruin, and G. E. Neurohr. Genome homeostasis defects drive enlarged cells into senescence. Molecular Cell, November 2023.
Matthews H., Bertoli C., and de Bruin R.A.M. Cell cycle control in cancer. Nature Reviews Molecular Cell Biology. 2022.
Pennycook B., Vesela E., Peripolli S., Singh T., Barr A.R., Bertoli C., de Bruin R.A.M. E2F-dependent transcription determines replication capacity and S phase length. Nature Communications. 2020 Jul 14;11(1):3503.
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de Bruin Lab
Click to email. r.debruin@ucl.ac.uk