How does transcriptional regulation drive the plasticity of adult physiology, metabolism and lifespan? We are answering this question in the fruit fly, with a specific focus on animal ageing and a broad interest in gene regulation by all three eukaryotic, nuclear RNA polymerases.
Our principal funders
Selected publications
Bowen Xu, Alexander Hull, Olivia N. M. Hill, Naja Kobal, Enric Ureña, Linda Partridge , Nazif Alic. Loss of Pol III repressor Maf1 in neurons promotes longevity by preventing the age-related decline in 5S rRNA and translation. PLoS Biology 2025. DOI: /10.1371/journal.pbio.3003250
Yasir Malik, Yavuz Kulaberoglu, Shajahan Anver, Sara Javidnia, Gillian Borland, Rene Rivera, Stephen Cranwell, Danel Medelbekova, Tatiana Svermova, Jackie Thomson, Susan Broughton, Tobias von der Haar, Colin Selman, Jennifer M. A. Tullet, Nazif Alic. Disruption of tRNA biogenesis enhances proteostatic resilience, improves later-life health, and promotes longevity. PLoS Biology 2024. DOI:10.1371/journal.pbio.3002853
Guillermo Martínez Corrales, Mengjia Li, Tatiana Svermova, Alex Goncalves, Diana Voicu, Adam J. Dobson, Tony D. Southall, Nazif Alic. Transcriptional memory of dFOXO activation in youth curtails later-life mortality through chromatin remodeling and Xbp1. Nature Aging. Volume 2, pages 1176–1190 (2022)
Danny Filer, Maximillian A. Thompson, Vakil Takhaveev, Adam J. Dobson, Ilektra Kotronaki, James W. M. Green, Matthias Heinemann, Jennifer M. A. Tullet, Nazif Alic. RNA polymerase III limits longevity downstream of TORC1. Nature. Volume 552, pages 263–267 (2017)
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Contact us if you have any questions about the Alic Lab.
Alic Lab
Click to email. n.alic@ucl.ac.uk