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Gene and Cell Therapy Group

Developing gene and cell therapy for sight loss by translating basic research into new treatments

Research highlights

Transplantation of photoreceptors from retina grown ‘in a dish’


We have carried out the first successful transplant of light-sensitive photoreceptor cells taken from a synthetic retina, grown ‘in a dish’ from embryonic stem cells.

When transplanted into night-blind mice these cells appeared to develop normally, integrating into the existing retina and forming the nerve connections needed to transmit visual information to the brain.

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We are currently conducting two ground-breaking clinical trials:

The world's first gene therapy trial in the eye, testing the safety and efficacy of delivering the RPE65 gene to patients with Leber congenital amaurosis (LCA).


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Surgery during our clinical trial

Europe's first trial testing the safety of transplanting stem cell-derived retinal cells into the eyes of patients with Stargardt disease


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EyeTherapy information hub

Visit the EyeTherapy information hub for an in-depth look at our research, and the EyeTherapy blog for updates, newsletter and more

Page last modified on 23 jul 13 14:28


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